ASP9436
ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 1401807-89-3
- Formula: C25H25Cl2N5O2
- Molecular Weight:498.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
human PDE 10A 8 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice aged 5-
6 weeks, PCP (2.5 mg/10 mL/kg, sc))-induced hyper-locomotion; Three-day-old male ddY mice PCP (15 mg/kg)-induced hyper-locomotion[1] -
Dosage:1, 3, 10, 30 mg/kg;0.0001, 0.0003, 0.001, 0.003 mg/kg (Neonatal mouse)
-
Administration:p.o., single administration
-
Result:Attenuated locomotor activityn, with an ED50 of 7.0 mg/kg.
Improved visual-recognition memory impairment in neonatal PCP-treated mice by the oral administration at 0.001 and 0.003 mg/kg in a novel object
recognition test (NORT).
Chemical Information
-
CAS No. 1401807-89-3
-
Molecular Weight 498.40
-
Formula C25H25Cl2N5O2
-
SMILES
O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz