2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ASP9436

ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia.

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ASP9436

ASP9436 Chemical Structure

CAS No. : 1401807-89-3

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Description

ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia[1].

IC50 & Target[1]

human PDE 10A

8 nM (IC50)

In Vivo

ASP9436 (Compound 38 b) (0.001-30 mg/kg, p.o., single administration) attenuates locomotor activity and ameliorates visual recognition memory impairment in neonatal mice in the phencyclidine (PCP)-induced hyperlocomotion mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice aged 5-
6 weeks, PCP (2.5 mg/10 mL/kg, sc))-induced hyper-locomotion; Three-day-old male ddY mice PCP (15 mg/kg)-induced hyper-locomotion[1]
Dosage: 1, 3, 10, 30 mg/kg;0.0001, 0.0003, 0.001, 0.003 mg/kg (Neonatal mouse)
Administration: p.o., single administration
Result: Attenuated locomotor activityn, with an ED50 of 7.0 mg/kg.
Improved visual-recognition memory impairment in neonatal PCP-treated mice by the oral administration at 0.001 and 0.003 mg/kg in a novel object
recognition test (NORT).
Molecular Weight

498.40

Formula

C25H25Cl2N5O2
CAS No.
SMILES

O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ASP9436 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP94361401807-89-3ASP 9436ASP-9436Phosphodiesterase (PDE)PDE10A inhibitorschizophreniaICR miceddY miceInhibitorinhibitorinhibit

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