ASP9436
ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 1401807-89-3
- Formula: C25H25Cl2N5O2
- Molecular Weight:498.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
human PDE 10A 8 nM (IC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice aged 5-
6 weeks, PCP (2.5 mg/10 mL/kg, sc))-induced hyper-locomotion; Three-day-old male ddY mice PCP (15 mg/kg)-induced hyper-locomotion[1] -
Dosage:1, 3, 10, 30 mg/kg;0.0001, 0.0003, 0.001, 0.003 mg/kg (Neonatal mouse)
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Administration:p.o., single administration
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Result:Attenuated locomotor activityn, with an ED50 of 7.0 mg/kg.
Improved visual-recognition memory impairment in neonatal PCP-treated mice by the oral administration at 0.001 and 0.003 mg/kg in a novel object
recognition test (NORT).
Chemical Information
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CAS No. 1401807-89-3
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Molecular Weight 498.40
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Formula C25H25Cl2N5O2
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SMILES
O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASP9436 Related Classifications
HY-120291 Related Classifications
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