1401807-89-3
Chemical Structure
ASP9436
- CAS No.: 1401807-89-3
- Formula:C25H25Cl2N5O2
- Molecular Weight:498.40
IUPAC Name: 1-methyl-5-(1-methyl-3-((4-(1-methyl-1H-benzo[d]imidazol-4-yl)phenoxy)methyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one hydrochloride
InChIKey: TXXSLKUDIZOGSL-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
Biological Activity: ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia[1].
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ASP9436 | ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia. | |||||||||||||||||||||
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Keywords
