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fungal growth

" in MedChemExpress (MCE) Product Catalog:

117

阻害剤およびアゴニスト

1

蛍光色素

3

生化学アッセイ試薬

3

ペプチド

1

阻害性抗体

51

天然物

7

同位体標識化合物

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製品番号 製品名 Target 研究分野 構造式
  • HY-B0133
    Natamycin
    Maximum Cited Publications
    8 Publications Verification

    Pimaricin

    		 Environmental Pollutants Antibiotic Endogenous Metabolite Fungal Bacterial Infection
    Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
    Natamycin
  • HY-W012530
    Phenylpyruvic acid

    		Endogenous Metabolite PDI Infection Metabolic Disease
    Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
    Phenylpyruvic acid
  • HY-119726
    Fosmanogepix

    APX001; E1211

    		 Fungal Infection Inflammation/Immunology Cancer
    Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
    Fosmanogepix
  • HY-W017277
    (+)-Menthol

    D-Menthol

    		 Fungal Neurological Disease
    (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
    (+)-Menthol
  • HY-B0996
    Hexetidine

    NSC-17764

    		 Bacterial Fungal Infection Inflammation/Immunology
    Hexetidine (NSC-17764) is an orally active antibacterial and antifungal agent with broad antibacterial and antifungal activity. Hexetidine combined with IPBC potentiates strong fungal growth inhibition properties. Hexetidine at concentrations greater than 0.1% can cause oral ulceration. Additionally, Hexetidine improves its plaque inhibiting activities combined with zinc and has been confirmed the effectiveness on purulent wound along with ultrasound. Hexetidine is a promising candidate for research in fungus-related diseases and soft tissue purulent-inflammatory
    Hexetidine
  • HY-B0850
    Difenoconazole
    3 Publications Verification

    		 Environmental Pollutants Fungal Infection
    Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .
    Difenoconazole
  • HY-119847
    Abafungin

    BAY-W-6341

    		 Fungal Infection
    Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
    Abafungin
  • HY-113205
    15-keto-Prostaglandin E2

    15-keto-PGE2

    		 Endogenous Metabolite Prostaglandin Receptor STAT PPAR Fungal Drug Metabolite Cardiovascular Disease Infection Endocrinology Cancer
    15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier .
    15-keto-Prostaglandin E2
  • HY-135549
    Fluxapyroxad
    1 Publications Verification

    		 Environmental Pollutants Antibiotic Cytochrome P450 Fungal Succinate Dehydrogenase Infection Inflammation/Immunology
    Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species .
    Fluxapyroxad
  • HY-N8537
    Enfumafungin

    		Fungal Infection
    Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
    Enfumafungin
  • HY-W016153
    2-Bromo-4-methylphenol

    		Biochemical Assay Reagents Bacterial Fungal Infection
    2-Bromo-4-methylphenol is a versatile compound. 2-Bromo-4-methylphenol produces an iodine-like odor in reverse osmosis water and red wine matrices. 2-Bromo-4-methylphenol exhibits antibacterial properties and effectively inhibits the growth of bacteria and fungal. 2-Bromo-4-methylphenol is an important intermediate for a variety of organic compounds .
    2-Bromo-4-methylphenol
  • HY-B1324
    Oxiconazole nitrate
    2 Publications Verification

    Ro 13-8996

    		 Fungal Cytochrome P450 Antibiotic Infection Cancer
    Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
    Oxiconazole nitrate
  • HY-N1633
    1-Methoxycarbonyl-β-carboline

    		Fungal Infection
    1-Methoxycarbonyl-β-carboline is a phytopathogenic fungal growth inhibitor with moderate to weak in vitro antifungal activity. 1-Methoxycarbonyl-β-carboline can be used for the research of phytopathogenic fungal infections .
    1-Methoxycarbonyl-β-carboline
  • HY-100527
    AN2718

    		Fungal Infection
    AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
    AN2718
  • HY-N10895
    12-Hydroxyisobakuchiol

    		Fungal Infection
    12-Hydroxyisobakuchiol is a hemiterpenoid compound that can be isolated from the leaves of Psoralea glandulosa. 12-Hydroxyisobakuchiol inhibits mycelial growth of Botrytis cinerea in vitro. 12-Hydroxyisobakuchiol is applicable to research related to phytopathogenic fungal infections .
    12-Hydroxyisobakuchiol
  • HY-124833
    Quinalizarin

    		Casein Kinase Apoptosis Fungal Reactive Oxygen Species (ROS) Caspase MDM-2/p53 PARP Bcl-2 Family Akt ERK STAT JNK p38 MAPK CDK Infection Cancer
    Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections .
    Quinalizarin
  • HY-W984782
    Flindersine

    		GLUT Bacterial Fungal AMPK PPAR Reactive Oxygen Species (ROS) Apoptosis SOD Infection Metabolic Disease Cancer
    Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections .
    Flindersine
  • HY-N2519
    (E)-Coniferin

    (E)-Laricin

    		 Fungal Infection
    (E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization .
    (E)-Coniferin
  • HY-Y1058
    Benzohydroxamic acid

    BHA

    		 Fungal Infection
    Benzohydroxamic acid (BHA) is a chitin deacetylase (CDA) inhibitor with significant antifungal activity. The Ki values of BHA against the CDAs of Verticillium dahliae and Puccinia striiformis f. sp. tritici are 8.31 μM and 9.83 μM, respectively. Benzohydroxamic acid can restore the defense responses of infected host plants, upregulate the expression of defense-related genes, and reduce the growth and reproduction of fungi in plants. Benzohydroxamic acid can be used in the research of the field of controlling agricultural fungal diseases, such as various plant fungal diseases caused by Verticillium dahliae, Puccinia striiformis and other fungi, like cotton wilt and wheat stripe rust .
    Benzohydroxamic acid
  • HY-W115529
    Geranic acid

    Geranate; NSC 229335; GAGE

    		 Environmental Pollutants Fungal Tyrosinase Infection Cancer
    Geranic acid (Geranate) acts as a tyrosinase inhibitor and antifungal agent, with an IC50 value of 0.14-2.3 mM against mushroom tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma .
    Geranic acid
  • HY-B1948
    Diniconazole

    S-3308

    		 Fungal Infection
    Diniconazole (S-3308) is a newly developed fungicide. Diniconazole exhibits fungicidal activity against Bolrytis cintrca, Sordaria fumicola, Fusarium graminearum, Sclerotium cepivornm, and Bipolaris sorokiniana with IC50 values of 0.012, <0.001, 0.008, 0.02, and 0.06 mg/L, respectively. Diniconazole can be used in research related to the prevention and control of plant fungal diseases and plant growth regulation .
    Diniconazole
  • HY-117089
    Tetraconazole

    		Environmental Pollutants Fungal Infection
    Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
    Tetraconazole
  • HY-148071
    Epocholeone

    		Fungal Others
    Epocholeone is a growth regulator. Epocholeone can control fungal or physiological diseases of crops .
    Epocholeone
  • HY-B0850R
    Difenoconazole (Standard)

    		Reference Standards Fungal Infection
    Difenoconazole (Standard) is the analytical standard of Difenoconazole. This product is intended for research and analytical applications. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .
    Difenoconazole (Standard)
  • HY-N4283A
    (E)-Coniferyl alcohol

    		Fungal Infection
    (E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth .
    (E)-Coniferyl alcohol
  • HY-123779
    RWJ-49815

    		Bacterial Fungal Infection
    RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor . RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections .
    RWJ-49815
  • HY-N6772
    Cytochalasin E

    		Autophagy Cancer
    Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .
    Cytochalasin E
  • HY-N8420
    Thalifoline

    		Fungal Infection Cancer
    Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .
    Thalifoline
  • HY-Y0850U5
    PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

    Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

    		 Biochemical Assay Reagents Fungal Infection
    PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu 2+, Co 2+, Ni 2+ and Zn 2+ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .
    PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)
  • HY-W012530R
    Phenylpyruvic acid (Standard)

    		Reference Standards Endogenous Metabolite PDI Infection Metabolic Disease
    Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
    Phenylpyruvic acid (Standard)
  • HY-W016203
    Phenylpyruvic acid sodium

    Sodium phenylpyruvate

    		 Endogenous Metabolite PDI Infection Metabolic Disease
    Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
    Phenylpyruvic acid sodium
  • HY-N8744
    Vestitol

    (±)-Vestitol

    		 Fungal Infection
    Vestitol ((±)-Vestitol) is an isoflavonoid phytoalexin and Antifungal agent. Vestitol can be isolated from the leaves of Trifolium arvense. Vestitol inhibits the mycelial growth of Helminthosporium carbonum with a ED50 of 17 μg/mL. Vestitol can be used in the research of fungal infections (Helminthosporium carbonum-induced plant diseases) .
    Vestitol
  • HY-W774934
    Isopyrazam

    		Fungal
    Isopyrazam is a plant protection product with fungal activity. Isopyrazam exhibits excellent disease resistance on crops and effectively inhibits the growth of multiple plant pathogenic fungi. The application of Isopyrazam can significantly improve the yield and quality of crops.
    Isopyrazam
  • HY-N3344
    Macrocarpal C

    		Fungal Others
    Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation .
    Macrocarpal C
  • HY-W587956
    α-Guaiene

    		Fungal Infection
    α-Guaiene is a natural sesquiterpene and fungicidal agent found in Pogostemon cablin (patchouli) essential oil. α-Guaiene suppresses the growth of Aspergillus niger, Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. α-Guaiene can be used for the study of fungal infection .
    α-Guaiene
  • HY-B0133R
    Natamycin (Standard)

    Pimaricin (Standard)

    		 Reference Standards Fungal Endogenous Metabolite Antibiotic Bacterial Infection
    Natamycin (Standard) is the analytical standard of Natamycin. This product is intended for research and analytical applications. Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
    Natamycin (Standard)
  • HY-W047478
    3-Methylcarbazole

    NSC 10154

    		 Fungal Interleukin Related Infection Inflammation/Immunology Cancer
    3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .
    3-Methylcarbazole
  • HY-118330
    Apigeninidin chloride

    Gesneridin chloride; Apigenidin chloride

    		 Fungal Infection
    Apigeninidin (Gesneridin) chloride, a 3‐deoxyanthocyanidin, is a fungal growth inhibitor. Apigeninidin chloride is a bioactive red biocolorant .
    Apigeninidin chloride
  • HY-122955
    Xanthobaccin A

    		Antibiotic Fungal Bacterial Infection
    Xanthobaccin A is a potent antibiotic that can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A exhibits activity against fungi and G+ bacteria, induces zoospore immobilization and lysis, inhibits mycelial growth. Xanthobaccin A can be used for the research of beet damping-off disease, bacterial and fungal infection .
    Xanthobaccin A
  • HY-W017611
    4-Propylphenol

    		Environmental Pollutants Reactive Oxygen Species (ROS) Fungal DNA/RNA Synthesis Infection
    4-Propylphenol is a plant-derived phenolic compound. 4-Propylphenol causes an increase in ROS within the Fusarium graminearum cells, leading to damage to the DNA and cell membranes of the mycelia, effectively inhibiting the growth of the mycelia. 4-Propylphenol also has a growth inhibitory effect on walnut pathogenic fungi (C. gloeosporioides, C. siamense, A. alternata), with its EC50 ranging from 29.11 to 31.89 mg/L, and it also inhibits spore germination, with EC50 being 55.04-71.85 mg/L. 4-Propylphenol can be used in the research of fungal diseases in walnuts and wheat Fusarium head blight .
    4-Propylphenol
  • HY-P3906
    Melittin free acid

    		Fungal Apoptosis Phospholipase Reactive Oxygen Species (ROS) Infection
    Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .
    Melittin free acid
  • HY-111357
    Antifungal agent 2

    		Fungal Infection
    Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
    Antifungal agent 2
  • HY-119726A
    Fosmanogepix (tautomerism)

    APX001 (tautomerism); E1211 (tautomerism)

    		 Fungal Infection Inflammation/Immunology
    Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
    Fosmanogepix (tautomerism)
  • HY-138100
    Hyalodendrin

    (+)-Hyalodendrin

    		 Fungal Infection
    Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .
    Hyalodendrin
  • HY-N12877
    Ophiobolin H

    		Bacterial Infection
    Ophiobolin H is a fungal metabolite that can be isolated from Aspergillus ustus. Ophiobolin H inhibits growth of Bacillus subtilis cultures. Ophiobolin H induces hyperacusia in day-old chicks at rates up to 375 mg/kg .
    Ophiobolin H
  • HY-W414596
    Metconazole

    		Fungal Infection
    Metconazole is a 14α-demethylation inhibitor (DMI) fungicide. Metconazole inhibits fungal ergosterol biosynthesis, inhibits mycelial growth and conidial germ tube elongation. Metconazole reduces antioxidant enzyme activities. Metconazole reduces occurrence of Fusarium crown rot in wheat .
    Metconazole
  • HY-159666
    Nystatin A1

    		Antibiotic Fungal Infection
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi .
    Nystatin A1
  • HY-125721
    Tetranactin

    		Fungal Bacterial Antibiotic Infection
    Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin LD50 for intraperitoneal injection in mice is greater than 300 mg/kg, and the LD50 is greater than 15,000 mg/kg .
    Tetranactin
  • HY-149492
    Phosphatase-IN-1

    		Phosphatase Fungal Infection
    Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads .
    Phosphatase-IN-1
  • HY-B1324A
    Oxiconazole

    Ro 13-8996 free base

    		 Fungal Cytochrome P450 Antibiotic Infection Cancer
    Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
    Oxiconazole

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