1. Anti-infection
  2. Fungal
  3. Difenoconazole

Difenoconazole 

Cat. No.: HY-B0850 Purity: 99.82%
COA Handling Instructions

Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.

For research use only. We do not sell to patients.

Difenoconazole Chemical Structure

Difenoconazole Chemical Structure

CAS No. : 119446-68-3

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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100 mg USD 50 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth[1].

In Vitro

Difenoconazole inhibits the growth of Fusarium graminearum with an EC50 of 1.69-19.6 mg/L[2].
Difenoconazole inhibits growth of Alternaria solani, Fulvia fulva,Botrytis cinerea, and Rhizoctonia solani with EC50s of 0.131, 0.069, 0.297, and 0.252 mg/L, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Difenoconazole (0.25-2 mg/L; exposure for 96 h) induces a large suite of symptoms in embryonic development, including hatching inhibition, slow heart rate, growth regression and morphological deformities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish[1]
Dosage: 0.25, 0.5, 1, 1.5 and 2 mg/L
Administration: Exposure for 96 h
Result: Caused significant body color blackening and decrease in the heart rate of zebrafish larvae over 24 h at 0.5 mg/L.
Inhibited the growth weight of adult zebrafish measured after 14 days' exposure at 0.25 mg/L.
Molecular Weight

406.26

Formula

C19H17Cl2N3O3

CAS No.
SMILES

CC1OC(CN2N=CN=C2)(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3Cl)OC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (246.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4615 mL 12.3074 mL 24.6148 mL
5 mM 0.4923 mL 2.4615 mL 4.9230 mL
10 mM 0.2461 mL 1.2307 mL 2.4615 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Difenoconazole
Cat. No.:
HY-B0850
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