2. Anti-infection Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Fungal Caspase PARP Apoptosis
  4. Trifloxystrobin

Trifloxystrobin  (Synonyms: CGA 279202)

Cat. No.: HY-123230 Purity: 99.68%
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Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.

For research use only. We do not sell to patients.

Trifloxystrobin Chemical Structure

Trifloxystrobin Chemical Structure

CAS No. : 141517-21-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Trifloxystrobin:

Trifloxystrobin Related Antibodies

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

View All PARP Isoform Specific Products:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases[1][2][3][4][5].

IC50 & Target

Caspase 3

 

Caspase-8

 

Caspase-9

 

In Vitro

Trifloxystrobin (2-500 μM, 24-48 h) reduces the viability of HaCaT cells[1].
Trifloxystrobin (0.5 μM, 48 h) induces apoptosis via the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated pathway in HaCaT cells[1].
Trifloxystrobin (25-200 μM, 4-48 h) have neurotoxicity in differentiated human SH-SY5Y cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trifloxystrobin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HaCaT cell
Concentration: 2 μM, 3.91 μM, 7.81 μM, 14.63 μM, 31.25 μM, 62.50 μM, 125 μM, 250 μM, 500 μM
Incubation Time: 24 h, 48 h
Result: Decreased the cell viability in a concentration-dependent manner.
Showed the IC50 value of cell viability at 24 h was calculated to be 22.9 μM, and that at 48 h was 5.14 μM.

Apoptosis Analysis[1]

Cell Line: HaCaT cell
Concentration: 0.5 μM
Incubation Time: 24 h, 48 h
Result: Induced the expression of pro-apoptotic proteins, apaf-1, procasp-9, procasp-8, and cyt c. Observed both only Annexin V-FITC (green)-positive cells and Annexin V-FITC (green)-/PI (red)-positive cells.
In Vivo

Trifloxystrobin (30.0-58.6 μg/L, zebrafish embryos were exposed to trifloxystrobin for 96 h post-fertilization (hpf)) is highly toxic to zebrafish embryos[3].
Trifloxystrobin (Soils were prepared by spiking 50 g of soil with 1mL of trifloxystrobin-acetonitrile solution. Following mixing and acetonitrile volatilization, spiked soil was mixed with additional soil to prepare 500 g aliquots containing 0.1, 1.0 and 2.5 mg/kg trifloxystrobin for 7-56 days) induces oxidative stress and DNA damage in two soils[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos[3]
Dosage: 30.0 μg/L, 37.5 μg/L, 47.0 μg/L, 58.6 μg/L
Administration: Zebrafish embryos were exposed to trifloxystrobin
Result: Caused severe developmental abnormalities of zebrafish embryos.
Induced oxidative stress in embryos.
Changed the transcription of immune related genes of embryos.
Molecular Weight

408.37

Formula

C20H19F3N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C(C1=CC(C(F)(F)F)=CC=C1)=N\OCC2=C(C=CC=C2)/C(C(OC)=O)=N\OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (306.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4488 mL 12.2438 mL 24.4876 mL
5 mM 0.4898 mL 2.4488 mL 4.8975 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.17 mg/mL (5.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.17 mg/mL (5.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4488 mL 12.2438 mL 24.4876 mL 61.2190 mL
5 mM 0.4898 mL 2.4488 mL 4.8975 mL 12.2438 mL
10 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1219 mL
15 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0813 mL
20 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0609 mL
25 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
30 mM 0.0816 mL 0.4081 mL 0.8163 mL 2.0406 mL
40 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5305 mL
50 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2244 mL
60 mM 0.0408 mL 0.2041 mL 0.4081 mL 1.0203 mL
80 mM 0.0306 mL 0.1530 mL 0.3061 mL 0.7652 mL
100 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.6122 mL
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Trifloxystrobin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifloxystrobin141517-21-7CGA 279202CGA279202CGA-279202FungalCaspasePARPApoptosispoly ADP ribose polymerase HaCaT cellSH-SY5YZebrafish embryosFungicideInhibitorinhibitorinhibit

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