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Results for "

fr-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Folate Receptor (FR) (13) 5 alpha Reductase (1) 5-HT Receptor (1) ACSL Family (1) Acyltransferase (3) ADC Antibody (2) ADC Payload (1) Adenosine Deaminase (2) Adenosine Receptor (1) Aldose Reductase (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (24) Antibody-Drug Conjugates (ADCs) (2) Antifolate (10) Apoptosis (9) Autophagy (7) Bacterial (20) Biochemical Assay Reagents (10) Bradykinin Receptor (4) Calcium Channel (2) CaMK (2) Cathepsin (4) CD28 (1) Cholecystokinin Receptor (1) COX (2) Cytochrome P450 (1) Dengue Virus (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Dopamine Receptor (5) Drug Derivative (3) Drug Intermediate (3) Drug Metabolite (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Endothelin Receptor (1) ERK (2) FGFR (1) Filovirus (1) FKBP (7) Flavivirus (1) Fluorescent Dye (3) Fungal (6) Glycosidase (2) HDAC (3) Histamine Receptor (3) iGluR (1) Influenza Virus (1) Integrin (2) Isotope-Labeled Compounds (5) Leukotriene Receptor (1) Liposome (1) mAChR (1) MAP3K (1) Microtubule/Tubulin (2) Na+/H+ Exchanger (NHE) (3) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NO Synthase (4) p38 MAPK (2) Parasite (5) Peptide-Drug Conjugates (PDCs) (1) PGE synthase (1) Phosphatase (8) Phosphodiesterase (PDE) (3) PKC (2) Prostaglandin Receptor (4) PROTACs (1) Protease Activated Receptor (PAR) (1) Proton Pump (1) Reactive Oxygen Species (ROS) (1) Reference Standards (15) SF3B1 (2) Small Interfering RNA (siRNA) (2) Squalene Monooxygenase (2) Thrombin (1) Thymidylate Synthase (2) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) TRP Channel (1) VEGFR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (65) Cardiovascular Disease (21) Endocrinology (7) Infection (33) Inflammation/Immunology (34) Metabolic Disease (12) Neurological Disease (17)
Click Chemistry:	DBCO (5) Alkynes (2)
Oligonucleotides:	Aptamers (2) Liposome (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Polymers (6) siRNAs (2)

170

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Folate Receptor (FR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13756

Tacrolimus Maximum Cited Publications 101 Publications Verification FK506; Fujimycin; fr900506	Phosphatase FKBP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-N6707

Triacsin C 5+ Cited Publications WS 1228A; fr 900190	ACSL Family Parasite	Infection Cardiovascular Disease
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .

HY-15149

Romidepsin 65+ Cited Publications FK 228; fr 901228; NSC 630176	HDAC Apoptosis	Cancer
Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-19332

Kifunensine 10+ Cited Publications fr-900494	Glycosidase	Inflammation/Immunology
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-B1381

Cefixime 5+ Cited Publications fr-17027; FK-027; CL-284635	Antibiotic Bacterial	Infection Cancer
Cefixime (FR-17027) is an orally active antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .

HY-108599

DCP-LA 5+ Cited Publications fr236924	PKC CaMK Phosphatase Apoptosis	Neurological Disease
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( ²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .

HY-12275

FR 180204 20+ Cited Publications	Flavivirus Dengue Virus ERK Apoptosis	Cancer
FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC₅₀s of 0.51 μM (K_i=0.31 μM) and 0.33 μM (K_i=0.14 μM), respectively .

HY-124909A

FR054	Phosphatase	Cancer
FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; fr-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-117037

FR900359 4 Publications Verification	Apoptosis ERK	Cardiovascular Disease Cancer
FR900359 is a depsipeptide selective inhibitor of Gα_q/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin (HY-W250978A)-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .

HY-16212

FR901464	Biochemical Assay Reagents	Cancer
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

HY-B1381A

Cefixime trihydrate 5+ Cited Publications fr-17027 trihydrate; FK-027 trihydrate; CL-284635 trihydrate	Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .

HY-112853

Fosmidomycin sodium salt 2 Publications Verification fr-31564	Bacterial Antibiotic	Infection
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

HY-19806

Ceftolozane CXA-101 free base; fr264205 free base	Antibiotic Bacterial	Infection
Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L .

HY-101128

Bicyclomycin benzoate 2 Publications Verification fr2054	Bacterial Antibiotic	Infection
Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.

HY-14284

Nilvadipine FK235; fr34235	Calcium Channel	Cardiovascular Disease
Nilvadipine is a potent calcium channel antagonist, and the IC₅₀ value is around 0.1 nM.

HY-129077

FR179642	Drug Intermediate	Infection
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin . FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379 .

HY-116800

FR194921	Adenosine Receptor	Neurological Disease
FR194921 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with K_i value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity .

HY-100303A

FR194738 2 Publications Verification	Squalene Monooxygenase	Metabolic Disease
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-P990587

FR104 1 Publications Verification	CD28	Inflammation/Immunology
FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

HY-100303

FR194738 free base 2 Publications Verification	Squalene Monooxygenase	Metabolic Disease
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-P10501A

FRα-targeting peptide C7 TFA	Antifolate	Cancer
FRα-targeting peptide C7 TFA is a selective peptide ligand for folate receptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 TFA can be used in the research of tumor diagnosis and treatment .

HY-123370

FR-167356	Proton Pump	Metabolic Disease Cancer
FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC₅₀ values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss .

HY-U00027

Quinotolast sodium fr71021	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine, LTC₄ and PGD₂ release in a concentration-dependent manner.

HY-122817

FR900098 sodium	Antibiotic Parasite	Infection
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .

HY-15791

FR173657 FK-3657	Bradykinin Receptor	Inflammation/Immunology
FR173657 is an orally active bradykinin B2 receptor antagonist (IC₅₀: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED₅₀: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED₅₀: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease .

HY-105257

Pranazepide fr120480	Cholecystokinin Receptor	Inflammation/Immunology
Pranazepide (FR120480) is a selective cholecystokinin-1 receptor (CCK1-R) antagonist with an IC₅₀ of 0.67 nM against CCK1-R. Pranazepide is applicable for the research of pancreatic diseases .

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); fr-900520 (Standard); FK520 (Standard)	Reference Standards FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-15149G

Romidepsin FK 228; fr 901228; NSC 630176	HDAC Apoptosis	Cancer
Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-18754A

FR 167653 fr 167653 sulfate	p38 MAPK Autophagy	Endocrinology
FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo .

HY-120082

FR-182980	Acyltransferase	Metabolic Disease
FR-182980 is an orally active ACAT1 inhibitor (IC₅₀: 30 nM). FR-182980 has hypocholesterolemic activity and can be used for research of atherosclerosis .

HY-117390

FR-181074	Phosphodiesterase (PDE)	Cardiovascular Disease Metabolic Disease
FR-181074 is a selective and orally active PDE V inhibitor. FR-181074 can specifically block PDE V to inhibit the degradation of cyclic guanosine monophosphate (cGMP) in order to relax smooth muscle. FR-181074 can be used for the researches of cardiovascular disease and endocrinology, such as hypertension and erectile dysfunction .

HY-U00025

FR 58664	Others	Cardiovascular Disease
FR 58664 is a agent to treat heart failure disease.

HY-P1974

FR 901379 WF11899A	Antibiotic	Infection
FR901379 (WF11899A) is a novel echinocandin-type lipopeptide antibiotic. FR901379 is primarily produced by mutant strain M-7 of Coleophoma empetri F-11899 (FERM BP-2635) .

HY-103386

FR122047	COX	Inflammation/Immunology
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC₅₀ of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo .

HY-131896

FR144420 NOR4	NO Synthase	Cardiovascular Disease
FR144420 (NOR4) is an orally active nitric oxide (NO)-releasing agent with vasodilatory and antiplatelet effects. FR144420 induces cGMP-mediated vasodilation and inhibits platelet aggregation. FR144420 is promising for research of cardiovascular diseases, particularly angina pectoris and coronary artery spasm .

HY-100302

FR183998 free base	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology
FR183998 free base is a potent Na ⁺/H ⁺-exchange inhibitor, with IC₅₀s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH_i change in rat lymphocytes, rat and human platelets, respectively.

HY-P10501

FRα-targeting peptide C7	Antifolate	Cancer
FRα-targeting peptide C7 is a selective peptide ligand for folate receptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .

HY-N9710

Bis(methylthio)gliotoxin Bisdethiobis(methylthio)gliotoxin; fr 49175; Dimethylgliotoxin	Fungal	Infection
Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis .

HY-19332R

Kifunensine (Standard) fr-900494 (Standard)	Reference Standards Glycosidase Others	Inflammation/Immunology
Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.

HY-19275

FR-158999	Integrin	Cardiovascular Disease
FR-158999 is a potent orally active fibrinogen inhibitor. FR-158999 exhibits potent anti-platelet activities with a pIC₅₀ of 7.50. FR-158999 can be used for antithrombotic research .

HY-123376

FR-190997	Bradykinin Receptor	Neurological Disease
FR-190997 is a non-peptide Bradykinin B2 receptor selective agonist, K_i value is 9.8 nM. FR-190997 is also an effective antihypertensive agent .

HY-167653

FR-145715	Histamine Receptor Bacterial	Infection
FR-145715 is a histamine H2 receptor antagonist, with specific anti-Helicobacter pylori activities. FR-145715 can be used for the research of gastric lesions .

HY-105375

FR 901537	Cytochrome P450	Cancer
FR 901537 is a potent and competitive aromatase inhibitor. FR 901537, a novel naphthol derivative, has the potential for breast cancer research .

HY-105686

FR-229934	Phosphodiesterase (PDE)	Cardiovascular Disease
FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1. FR-229934 can be used for the research of pulmonary arterial hypertension and erectile dysfunction .

HY-116613

FR-181877	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
FR-181877 (compound 4) is a non-prostaglandin PGI₂ agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC₅₀ value of 0.081 μM .

HY-121431

FR-901235	Fungal	Inflammation/Immunology
FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice .

HY-105485

FR-62765	Aldose Reductase	Neurological Disease Metabolic Disease
FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy .

HY-119728

FR198248	Influenza Virus	Infection
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

HY-U00146

FR-188582	COX	Inflammation/Immunology
FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC₅₀ value of 17 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13756

Tacrolimus Maximum Cited Publications 101 Publications Verification FK506; Fujimycin; fr900506	Infection Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Source Classification	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-N6707

Triacsin C 5+ Cited Publications WS 1228A; fr 900190	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	ACSL Family Parasite
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .

HY-19332

Kifunensine 10+ Cited Publications fr-900494	Alkaloids Piperidine Alkaloids Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Glycosidase
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-12686

5Z-7-Oxozeaenol 25+ Cited Publications fr148083; L783279; LL-Z 1640-2	Natural Products Monophenols Microorganisms Classification of Application Fields Phenols Inflammation/Immunology Disease Research Fields Source Classification	MAP3K VEGFR Antibiotic
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

HY-13756A

Tacrolimus monohydrate Maximum Cited Publications 101 Publications Verification FK506 monohydrate; Fujimycin monohydrate; fr900506 monohydrate	Infection Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Source Classification	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; fr-900520; FK520	Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Neurological Disease Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Source Classification	FKBP Parasite Fungal Antibiotic
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-117037

FR900359 4 Publications Verification	Structural Classification Ardisia crenata Sims Ketones, Aldehydes, Acids Plants Myrsinaceae Source Classification	Apoptosis ERK
FR900359 is a depsipeptide selective inhibitor of Gα_q/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin (HY-W250978A)-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .

HY-16212

FR901464	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Biochemical Assay Reagents
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

HY-129077

FR179642	Infection Monophenols Microorganisms Classification of Application Fields Cyclopeptides Phenols Disease Research Fields Source Classification	Drug Intermediate
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin . FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379 .

HY-13756R

Tacrolimus (Standard) FK506 (Standard); Fujimycin (Standard); fr900506 (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Antibiotics Disease Research Source Classification	Reference Standards Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); fr-900520 (Standard); FK520 (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Antibiotics Disease Research Source Classification	Reference Standards FKBP Parasite Fungal Antibiotic
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-118736

Ganodermic acid S	Triterpenes Microorganisms Ketones, Aldehydes, Acids Terpenoids Source Classification	Others
Ganodermic acid S is an oxygenated triterpenoid, that can be isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae). Ganodermic acid S exerts a concentration dependent inhibition on the response of human gel-filtered platelets (GFP) to U-46619 (HY-108566), a thromboxane (TX) A2 mimetic .

HY-P1974

FR 901379 WF11899A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
FR901379 (WF11899A) is a novel echinocandin-type lipopeptide antibiotic. FR901379 is primarily produced by mutant strain M-7 of Coleophoma empetri F-11899 (FERM BP-2635) .

HY-113629R

2-Keto-D-Glucose (Standard) D-Glucosone (Standard); D-Arabino-hexos-2-ulose (Standard)	Endogenous metabolite Saccharides Source Classification	Drug Metabolite Reference Standards
Cefixime (trihydrate) (Standard) is the analytical standard of Cefixime (trihydrate). This product is intended for research and analytical applications. Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .

HY-N9710

Bis(methylthio)gliotoxin Bisdethiobis(methylthio)gliotoxin; fr 49175; Dimethylgliotoxin	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Fungal
Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis .

HY-19332R

Kifunensine (Standard) fr-900494 (Standard)	Alkaloids Piperidine Alkaloids Microorganisms Source Classification	Reference Standards Glycosidase Others
Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.

HY-105375

FR 901537	Monophenols Microorganisms Phenols Source Classification	Cytochrome P450
FR 901537 is a potent and competitive aromatase inhibitor. FR 901537, a novel naphthol derivative, has the potential for breast cancer research .

HY-121431

FR-901235	Microorganisms Phenols Polyphenols Source Classification	Fungal
FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice .

HY-119728

FR198248	Microorganisms Phenols Polyphenols Source Classification	Influenza Virus
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

HY-122341

Thrazarine fr 900840	Microorganisms Ketones, Aldehydes, Acids Source Classification	Antibiotic
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research .

HY-169796

Panepophenanthrin	Natural Products Microorganisms Source Classification	E1/E2/E3 Enzyme
Panepophenanthrin is a compound that can be isolated from the mushroom strain, Panus rudis Fr. IFO 8994. Panepophenanthrin is a ubiquitin-activating enzyme inhibitor .

HY-182569

FR 111142	Structural Classification Natural Products Microorganisms Source Classification	VEGFR
FR 111142 is an angiogenesis inhibitor (IC₅₀ = 18.4 μM) and has anti-inflammatory activity (IC₅₀ = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases .

HY-129077R

FR179642 (Standard)	Structural Classification Monophenols Microorganisms Cyclopeptides Phenols Source Classification	Reference Standards Drug Intermediate
FR179642 (Standard) is the analytical standard of FR179642. This product is intended for research and analytical applications. FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin[1]. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379[2].

HY-N10240

9-Demethyl FR-901235	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Inflammation/Immunology Source Classification	Others
9-Demethyl FR-901235 is the 9-demethyl derivative of immunomodulator FR-901235 .

HY-118915

FR 106969 A26771E	Microorganisms Antibiotics Source Classification	Endogenous Metabolite
FR 106969 (A26771E) is a platelet activating factor antagonist with anti-inflammatory activity. FR 106969 can be used to alleviate inflammatory responses. FR 106969 has shown potential inhibitory effects on inflammation-related diseases in studies .

Cat. No.	Product Name	Chemical Structure

HY-13756S

Tacrolimus-13C,d2 1 Publications Verification
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13756S2

Tacrolimus-d3
Tacrolimus-d₃ (FK506-d₃) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-15149S2

Romidepsin-d7

Romidepsin-d₇ (FK 228-d₇) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-Y1322S

Triphenyl phosphate-d15
Triphenyl phosphate-d₁₅ is the deuterium labeled Triphenyl phosphate .

HY-173106S

YTASD(Leu-13C6,15N)FR TFA
YTASD(Leu- ¹³C₆, ¹⁵N)FR TFA is the ¹³C- and ¹⁵N-labeled YTASD(Leu)FR TFA.

HY-19806S1

Ceftolozane-15N2,d4 TFA
Ceftolozane- ¹⁵N₂,d₄ (CXA-101- ¹⁵N₂,d₄) TFA is the ¹⁵N- and deuterium-labeled Ceftolozane TFA (HY-106257A). Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections. Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer .

Targets Recommended: Folate Receptor (FR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure