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Cat. No.: HY-103231

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(S)-CPW 399

(S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, with a 20-fold higher selectivity for GluA1 and GluA2 subunits over GluA3 and GluA4 subunits. (S)-CPW 399 can significantly increase the spontaneous firing rate (FR) of LC noradrenergic neurons by activating AMPA receptors containing GluA1 subunits. (S)-CPW 399 can be used for the study of neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 389888-02-2
Formula: C₁₀H₁₃N₃O₄
Molecular Weight:239.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(S)-CPW 399 Chemical Structure

CAS No.: 389888-02-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	EC₅₀	13.9 μM Compound: (S)-1, (S)-CPW399	Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR2(Q) expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR2(Q) expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method	[PMID: 18811139]
Oocyte	EC₅₀	13.9 μM Compound: 2b	The potency at recombinant rat AMPA-R was measured on receptor Ionotropic glutamate receptor AMPA 2 expressed in Xenopus Laevis oocytes The potency at recombinant rat AMPA-R was measured on receptor Ionotropic glutamate receptor AMPA 2 expressed in Xenopus Laevis oocytes	[PMID: 11741469]
Oocyte	EC₅₀	224 μM Compound: (S)-1, (S)-CPW399	Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR3 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR3 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method	[PMID: 18811139]
Oocyte	EC₅₀	224 μM Compound: 2b	The potency at recombinant rat AMPA-R was measured on Ionotropic glutamate receptor AMPA 3 expressed in Xenopus Laevis oocytes The potency at recombinant rat AMPA-R was measured on Ionotropic glutamate receptor AMPA 3 expressed in Xenopus Laevis oocytes	[PMID: 11741469]
Oocyte	EC₅₀	24.9 μM Compound: (S)-1, (S)-CPW399	Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method	[PMID: 18811139]
Oocyte	EC₅₀	24.9 μM Compound: 2b	The potency at recombinant rat AMPA-R was measured on GluR1 receptor expressed in Xenopus Laevis oocytes The potency at recombinant rat AMPA-R was measured on GluR1 receptor expressed in Xenopus Laevis oocytes	[PMID: 11741469]
Oocyte	EC₅₀	34.3 μM Compound: (S)-1, (S)-CPW399	Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR4c expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR4c expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method	[PMID: 18811139]
Oocyte	EC₅₀	34.3 μM Compound: 2b	The potency at recombinant rat AMPA-R was measured on GluR4 receptor expressed in Xenopus Laevis oocytes The potency at recombinant rat AMPA-R was measured on GluR4 receptor expressed in Xenopus Laevis oocytes	[PMID: 11741469]
Oocyte	EC₅₀	9.87 μM Compound: (S)-2, ((S)CPW399	Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology	[PMID: 21619066]

Chemical Information

CAS No. 389888-02-2
Molecular Weight 239.23
Formula C₁₀H₁₃N₃O₄
SMILES

OC([C@@H](N)CN1C2=C(CCC2)C(NC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kelly L, et al. Subunit-specific expression and function of AMPA receptors in the mouse locus coeruleus. J Anat. 2023 Nov;243(5):813-825. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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(S)-CPW 399

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(S)-CPW 399 Related Classifications

HY-103231 Related Classifications