389888-02-2
Chemical Structure
(S)-CPW 399
- CAS No.: 389888-02-2
- Formula:C10H13N3O4
- Molecular Weight:239.23
IUPAC Name: (S)-2-amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)propanoic acid
InChIKey: VSGUEKZRMJVQOH-LURJTMIESA-N
SMILES: OC([C@@H](N)CN1C2=C(CCC2)C(NC1=O)=O)=O
Biological Activity: (S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, with a 20-fold higher selectivity for GluA1 and GluA2 subunits over GluA3 and GluA4 subunits. (S)-CPW 399 can significantly increase the spontaneous firing rate (FR) of LC noradrenergic neurons by activating AMPA receptors containing GluA1 subunits. (S)-CPW 399 can be used for the study of neurological diseases[1].
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(S)-CPW 399 | (S)-CPW 399 is a subtype-selective full agonist of AMPA receptors, with a 20-fold higher selectivity for GluA1 and GluA2 subunits over GluA3 and GluA4 subunits. (S)-CPW 399 can significantly increase the spontaneous firing rate (FR) of LC noradrenergic neurons by activating AMPA receptors containing GluA1 subunits. (S)-CPW 399 can be used for the study of neurological diseases. | |||||||||||||||||||||
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