Fosmidomycin sodium salt
Based on 2 publication(s) in Google Scholar
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.
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- Purity : 99.72%
- CAS No.: 66508-37-0
- 화학식: C4H9NNaO5P
- 분자량:205.08
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fosmidomycin sodium salt
MoreAll Antibiotic Isoforms
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | CC50 |
>64 μM
Compound: 1
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Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
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[PMID: 30879839] |
| MRC5 | CC50 |
>64 μM
Compound: 1
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
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[PMID: 36399924] |
| MRC5 | IC50 |
>64 μM
Compound: 1
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Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
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[PMID: 30344904] |
In Vitro
Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 66508-37-0
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Appearance Solid
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분자량 205.08
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화학식 C4H9NNaO5P
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Color White to light brown
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SMILES
OP(CCCN(C=O)O)(O[Na])=O
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Synonyms
FR-31564
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Plant Sci
Adjusting function of camphor on primary metabolism in Cinnamomum camphora stressed by high temperature. [Abstract]2024 Feb:339:111956. PMID: 38101618 -
ACS Infect Dis
Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum. [Abstract]2024 Dec 13;10(12):4073-4086. PMID: 39631773
용액&용해도
In Vitro:
H2O : 25 mg/mL (121.90 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (487.61 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8. [Content Brief]
[2]. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90. [Content Brief]
[3]. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8761 mL | 24.3807 mL | 48.7615 mL | 121.9036 mL |
| 5 mM | 0.9752 mL | 4.8761 mL | 9.7523 mL | 24.3807 mL | |
| 10 mM | 0.4876 mL | 2.4381 mL | 4.8761 mL | 12.1904 mL | |
| 15 mM | 0.3251 mL | 1.6254 mL | 3.2508 mL | 8.1269 mL | |
| 20 mM | 0.2438 mL | 1.2190 mL | 2.4381 mL | 6.0952 mL | |
| 25 mM | 0.1950 mL | 0.9752 mL | 1.9505 mL | 4.8761 mL | |
| 30 mM | 0.1625 mL | 0.8127 mL | 1.6254 mL | 4.0635 mL | |
| 40 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0476 mL | |
| 50 mM | 0.0975 mL | 0.4876 mL | 0.9752 mL | 2.4381 mL | |
| 60 mM | 0.0813 mL | 0.4063 mL | 0.8127 mL | 2.0317 mL | |
| 80 mM | 0.0610 mL | 0.3048 mL | 0.6095 mL | 1.5238 mL | |
| 100 mM | 0.0488 mL | 0.2438 mL | 0.4876 mL | 1.2190 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fosmidomycin sodium salt Related Classifications
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