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Cat. No.: HY-N9710

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Bis(methylthio)gliotoxin

(Synonyms: Bisdethiobis(methylthio)gliotoxin; FR 49175; Dimethylgliotoxin)

Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.

For research use only. We do not sell to patients.

CAS No.: 74149-38-5
Formula: C₁₅H₂₀N₂O₄S₂
Molecular Weight:356.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Bis(methylthio)gliotoxin Chemical Structure

CAS No.: 74149-38-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>2.81 μM Compound: 3	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 20303767]
HUVEC	IC₅₀	1.12 μM Compound: 3	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 20303767]
Jurkat	IC₅₀	140 μM Compound: 3	Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay	[PMID: 20303767]
Macrophage	ED₅₀	>10 μM Compound: 3	Immunomodulatory activity in macrophage assessed as inhibition of phagocytosis Immunomodulatory activity in macrophage assessed as inhibition of phagocytosis	[PMID: 20303767]
P388	IC₅₀	0.11 μM Compound: 3	Cytotoxicity against mouse P388 cells after 96 hrs by MTT assay Cytotoxicity against mouse P388 cells after 96 hrs by MTT assay	[PMID: 22148349]
PC-3	IC₅₀	0.39 μM Compound: 310	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 38181652]
U-937	IC₅₀	0.2 μM Compound: 310	Cytotoxicity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38181652]

Chemical Information

CAS No. 74149-38-5
Molecular Weight 356.46
Formula C₁₅H₂₀N₂O₄S₂
SMILES

CS[C@]12N(C([C@@](SC)(N(C2=O)C)CO)=O)[C@@]3([H])C(C1)=CC=C[C@@H]3O
Synonyms

Bisdethiobis(methylthio)gliotoxin; FR 49175; Dimethylgliotoxin
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
genus Aspergillus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Domingo MP, et al. Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis. Diagn Microbiol Infect Dis. 2012;73(1):57-64. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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