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Cat. No.: HY-185743

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ZW-191

ZW-191 is an antibody-drug conjugate (ADC) targeting folate receptor α (FRα). ZW-191 consists of ZW-191 Antibody (HY-P992515) as the antibody component and MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360) as the linker-payload component. ZW-191 possesses excellent tumor sphere penetration, cellular internalization and payload delivery capabilities, and can release a topoisomerase 1 inhibitor inside tumor cells to inhibit tumor cell activity. ZW-191 exerts a potent bystander effect on both antigen-positive and antigen-negative cells. ZW-191 exhibits prominent activity in xenograft models of cell lines with different FRα expression levels. ZW-191 can be used in studies related to ovarian cancer, non-small cell lung cancer, endometrial cancer and triple-negative breast cancer.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

ZW-191 Chemical Structure

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

FR-α

All Folate Receptor (FR) Isoforms :

FR-α

In Vitro

ZW-191 shows detectable apparent binding affinity in FRα-expressing cells. ZW-191 mediates superior cellular internalization and payload delivery compared with other FRα-targeted antibodies applied in different ADCs^[1].
ZW191 demonstrates strong FRα binding, superior tumor spheroid penetration, cellular internalization, and cytotoxic activity in FRα-expressing cancer cells^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZW-191 exerts potent antitumor activity in cell line-derived xenograft and patient-derived xenograft models covering different FRα expression levels. ZW-191 maintains favorable tolerability in rodents after two administrations at a dose of 200 mg/kg. ZW-191 exhibits satisfactory safety profiles in non-human primates when given twice at a dose of 30 mg/kg. ZW-191 displays optimal pharmacokinetic characteristics in rodents and non-human primates during in vivo assessments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[ZW-191]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lawn S, et al. Abstract 2641: ZW191, a novel FRa-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload. Cancer Research. 2023;83(7_Supplement):2641.

[2]. Lawn S, et al. Abstract 1862: ZW191 - a FRα-targeting antibody drug conjugate with strong preclinical activity across multiple FRα-expressing indications. Cancer Research. 2024;84(6_Supplement):1862.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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ZW-191

All Folate Receptor (FR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZW-191 Related Classifications

HY-185743 Related Classifications