ZW-191 Antibody
ZW-191 Antibody is a humanized IgG1 antibody targeting folate receptor α (FRα). ZW-191 Antibody is conjugated with MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360) to generate the antibody-drug conjugate (ADC) ZW-191 (HY-185743). ZW-191 Antibody-based ADC exerts a potent bystander effect on both antigen-positive and antigen-negative cells. ZW-191 Antibody is applicable to research related to ovarian cancer, non-small cell lung cancer, endometrial cancer, and triple-negative breast cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
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FR-α |
ZW-191 Antibody serves as the core scaffold for constructing the intact antibody-drug conjugate ZW-191 (HY-185743). ZW-191 is an antibody-drug conjugate formed by the conjugation of ZW-191 Antibody, a linker, and the topoisomerase 1 inhibitor payload ZD06519 (HY-156513), and achieves targeted action by virtue of the folate receptor α-binding property of ZW-191 Antibody[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
FOLR1/FRA
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZW-191 Antibody Related Classifications
HY-P992515 Related Classifications
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