Triphenyl phosphate-d₁₅  (Synonyms: Celluflex TPP-d₁₅; DHPF 005-d₁₅; Disflamol TP-d₁₅; Disflamoll TP-d₁₅; NSC 57868-d₁₅; Phenyl phosphate ((PhO)3PO)-d₁₅; Phoscon FR 903N-d₁₅)

Triphenyl phosphate-d₁₅ is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

341.38

C₁₈D₁₅O₄P

1173020-30-8

115-86-6

Solid

White to off-white

[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1OP(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(OC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])=O

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]