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  4. Triacsin C

Triacsin C  (Synonyms: WS 1228A; FR 900190)

Cat. No.: HY-N6707 Purity: ≥99.0%
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Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C is found to be highly effective against rotavirus replication.

For research use only. We do not sell to patients.

Triacsin C Chemical Structure

Triacsin C Chemical Structure

CAS No. : 76896-80-5

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Based on 3 publication(s) in Google Scholar

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Description

Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2].

IC50 & Target

IC50: 3.70 μM (CpACS1), 2.32 μM (CpACS2)[3]
In Vitro

Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triacsin C Related Antibodies
In Vivo

Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases[3].
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cryptosporidium-infected interleukin knockout mice[3]
Dosage: 8-15 mg/kg/d
Administration: Oral gavage; 1 week
Result: Reduced parasite oocyst production up to 88.1% with no apparent toxicity.
Animal Model: Low-density lipoprotein receptor-knockout (LDLR-/-) mice (C57BL/6 background)[4]
Dosage: 10 mg/kg/d
Administration: Oral gavage; 2 months
Result: Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.
Molecular Weight

207.27

Formula

C11H17N3O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CCC/C=C/C/C=C/C=C/C=N/NN=O
Structure Classification
Initial Source

Streptomyces aureofaciens
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (24.12 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8246 mL 24.1231 mL 48.2462 mL
5 mM 0.9649 mL 4.8246 mL 9.6493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.08%

COA (239 KB) RP-HPLC (236 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8246 mL 24.1231 mL 48.2462 mL 120.6156 mL
5 mM 0.9649 mL 4.8246 mL 9.6492 mL 24.1231 mL
10 mM 0.4825 mL 2.4123 mL 4.8246 mL 12.0616 mL
15 mM 0.3216 mL 1.6082 mL 3.2164 mL 8.0410 mL
20 mM 0.2412 mL 1.2062 mL 2.4123 mL 6.0308 mL
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Triacsin C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triacsin C76896-80-5WS 1228A FR 900190FR900190FR 900190FR-900190Parasitecryptosporidium parvumcryptosporidiosislong chain fatty acyl-CoA synthetaseanticryptosporidial efficacyInhibitorinhibitorinhibit

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