2. Metabolic Enzyme/Protease Anti-infection
  3. ACSL Family Parasite
  4. Triacsin C

Triacsin C  (Synonyms: WS 1228A; FR 900190)

Cat. No.: HY-N6707 Purity: 98.71%
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Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C exhibits highly inhibitory effect against rotavirus replication.

For research use only. We do not sell to patients.

CAS No. : 76896-80-5

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Based on 8 publication(s) in Google Scholar

Triacsin C Related Antibodies

Top Publications Citing Use of Products

    Triacsin C purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2026 Jan;16(1):e70563.  [Abstract]

    Triacsin C (2 mg/kg, i.p., 24 h) reduced LIRI-induced lung injury in male C57BL/6J mice.

    Triacsin C purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2026 Jan;16(1):e70563.  [Abstract]

    Triacsin C (5 μM, 8 h) preserved zonula occludens-1 (ZO-1) expression in MLE-12 cells.

    Triacsin C purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Apr 10:587:216696.  [Abstract]

    Triacsin C (1 and 5 μM, 12 h) decreased LDHA palmitoylation in PANC1 cells labeled with 50 μM alk-C16 for 8 h using the CCR method.

    Triacsin C purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2319582121.  [Abstract]

    Triacsin C (5 μM, 4 days) blocked the accumulation of triacylglycerol in lipid droplets, resulting in enlarged but reduced numbers of lipid droplets in the V. mali (QX-4-5) strain.

    Triacsin C purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2319582121.  [Abstract]

    Triacsin C (5 μM, 4 days) increased the accumulation of VmNSRV1 genomic RNA in the V. mali(QX-4-5) strain.

    View All ACSL Family Isoform Specific Products:

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    ACSL4 ACSL5

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    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C exhibits highly inhibitory effect against rotavirus replication[2].

    IC50 & Target

    ACSL4

     

    In Vitro

    Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].
    Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].
    Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Triacsin C Related Antibodies
    In Vivo

    Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases[3].
    Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Cryptosporidium-infected interleukin knockout mice[3]
    Dosage: 8-15 mg/kg/d
    Administration: Oral gavage; 1 week
    Result: Reduced parasite oocyst production up to 88.1% with no apparent toxicity.
    Animal Model: Low-density lipoprotein receptor-knockout (LDLR-/-) mice (C57BL/6 background)[4]
    Dosage: 10 mg/kg/d
    Administration: Oral gavage; 2 months
    Result: Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
    Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.
    Molecular Weight

    207.27

    Formula

    C11H17N3O
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to brown

    SMILES

    CCC/C=C/C/C=C/C=C/C=N/NN=O
    Structure Classification
    Initial Source

    Streptomyces aureofaciens
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (24.12 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.8246 mL 24.1231 mL 48.2462 mL
    5 mM 0.9649 mL 4.8246 mL 9.6493 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.08%

    SDS (394 KB)

    COA (239 KB) RP-HPLC (236 KB) MS (71 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.8246 mL 24.1231 mL 48.2462 mL 120.6156 mL
    5 mM 0.9649 mL 4.8246 mL 9.6492 mL 24.1231 mL
    10 mM 0.4825 mL 2.4123 mL 4.8246 mL 12.0616 mL
    15 mM 0.3216 mL 1.6082 mL 3.2164 mL 8.0410 mL
    20 mM 0.2412 mL 1.2062 mL 2.4123 mL 6.0308 mL
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    Triacsin C Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Triacsin C76896-80-5WS 1228A FR 900190FR900190FR 900190FR-900190ACSL FamilyParasitecryptosporidium parvumcryptosporidiosislong chain fatty acyl-CoA synthetaseanticryptosporidial efficacyInhibitorinhibitorinhibit

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