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  2. Parasite
  3. Triacsin C

Triacsin C  (Synonyms: WS 1228A; FR 900190)

Cat. No.: HY-N6707 Purity: ≥95.0%
COA Handling Instructions

Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C is found to be highly effective against rotavirus replication.

For research use only. We do not sell to patients.

Triacsin C Chemical Structure

Triacsin C Chemical Structure

CAS No. : 76896-80-5

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500 μg USD 700 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2].

IC50 & Target

IC50: 3.70 μM (CpACS1), 2.32 μM (CpACS2)[3]

In Vitro

Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases[3].
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cryptosporidium-infected interleukin knockout mice[3]
Dosage: 8-15 mg/kg/d
Administration: Oral gavage; 1 week
Result: Reduced parasite oocyst production up to 88.1% with no apparent toxicity.
Animal Model: Low-density lipoprotein receptor-knockout (LDLR-/-) mice (C57BL/6 background)[4]
Dosage: 10 mg/kg/d
Administration: Oral gavage; 2 months
Result: Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.
Molecular Weight

207.27

Formula

C11H17N3O

CAS No.
SMILES

CCC/C=C/C/C=C/C=C/C=N/NN=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (24.12 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8246 mL 24.1231 mL 48.2462 mL
5 mM 0.9649 mL 4.8246 mL 9.6493 mL
10 mM 0.4825 mL 2.4123 mL 4.8246 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.08%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Triacsin C
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HY-N6707
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