1. Apoptosis
  2. Thymidylate Synthase
  3. ONX 0801 trisodium

ONX 0801 trisodium (Synonyms: BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium)

Cat. No.: HY-10822A
Handling Instructions

ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors.

For research use only. We do not sell to patients.

ONX 0801 trisodium Chemical Structure

ONX 0801 trisodium Chemical Structure

CAS No. : 1097638-00-0

Size Price Stock
5 mg USD 2850 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors[1][2].

In Vitro

ONX 0801 (BGC 945) is designed to further reduce toxicity by more effectively targeting cancer cells that overexpress the α-FR[1].
ONX 0801 (BGC 945) exhibits IC50 values of of 6.6 μM, 1.1 nM, 3.3 nM, 90 nM and 0.32 μM in A431, A431-FBP, KB, IGROV-1 and JEG-3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BGC 945 (100 mg/kg, ip/iv injection) in the tumor had a longer half-life (28 hours) compared with other tissues[2].
BGC 945 (100 mg/kg daily for 16 days) does not lead to body weight loss, macroscopic signs of toxicity to the major organs, or a change in renal function[2].
BGC 945 at 100mg/kg induces a 5-20-fold increase in tumor dUrd at 4-72h without increases in the plasma, consistent with tumor targeting[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (on the folate-free diet for 5 days were transplanted with tumor and the implants)[2].
Dosage: 100 mg/kg (Pharmacokinetic Analysis).
Administration: Single i.p. or iv injection.
Result: After i.p. injection, the compound was well absorbed from the peritoneal cavity. The plasma AUC was 50% higher for i.p. compared with i.v. administration and was also higher in spleen, kidney, and liver by this route. Tumor AUC was similar via either route.
Molecular Weight

713.58

Formula

C₃₂H₃₀N₅Na₃O₁₀

CAS No.

1097638-00-0

SMILES

O=C(N[[email protected]](C(O[Na])=O)CCC(N[[email protected]@H](C(O[Na])=O)CCC(O[Na])=O)=O)C1=CC=C(N([[email protected]]2CCC3=C2C=C4C(NC(CO)=NC4=O)=C3)CC#C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ONX 0801 trisodiumBGC 945 trisodiumIdetrexed trisodiumCB 300945 trisodiumThymidylate SynthaseOvariancancerfolatereceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ONX 0801 trisodium
Cat. No.:
HY-10822A
Quantity:
MCE Japan Authorized Agent: