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FR054 

Cat. No.: HY-124909A
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FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect.

For research use only. We do not sell to patients.

FR054 Chemical Structure

FR054 Chemical Structure

CAS No. : 35954-65-5

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Description

FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].

In Vitro

FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1].
FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells[1].
FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells.
Concentration: 0.5-1 mM.
Incubation Time: 48 h.
Result: Reduced viability and a significant increase of the apoptosis as compared to the control clone.
In Vivo

FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice were subcutaneously injected with MDA-MB-231 cells[1].
Dosage: 1000 mg/kg.
Administration: IP, single or fractionated dose (twice a day 500 mg/kg/dose).
Result: Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.
Molecular Weight

329.30

Formula

C₁₄H₁₉NO₈

CAS No.
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FR054
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HY-124909A
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