FR167344 free base
FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65 nM and no binding affinity for the B1 receptor.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 215258-13-2
- Formule: C30H28BrCl2N5O4
- Masse moléculaire:673.38
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-17446
IcatibantBradykinin Receptor Antagonist -
HY-15039
SSR240612 -
HY-15043
ELN-441958Bradykinin B1 Receptor Antagonist -
HY-17446R
Icatibant (Standard)Bradykinin Receptor Antagonist -
HY-103290
R715Bradykinin B1 Receptor Antagonist -
HY-121156A
Anatibant hydrochlorideBradykinin B2 Receptor Antagonist -
HY-147273
FulimetibantBradykinin Receptor Antagonist -
![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-BradykininB1 Receptor Agonist -
HY-103289
MEN 11270B2 Kinin Receptor Antagonist -
HY-103293
Lys-BradykininKallidin -
![Lys-[Des-Arg9]Bradykinin](https://file.medchemexpress.com/product_pic/hy-103295.gif)
HY-103295
Lys-[Des-Arg9]BradykininBradykinin B1 Receptor Agonist -
HY-103296
Bombinakinin MBradykinin Receptor Agonist
Voir tous les produits spécifiques à Isoform Bradykinin Receptor
More
Activité biologique
Description
IC50 & Target
|
Bradykinin B2 Receptor (B2R) |
In Vitro
In competitive experiments using membranes prepared from Chinese hamster ovary cells expressing the bradykinin receptor subtypes, FR167344 shows a high affinity binding to the B2 receptor with IC50 values of 65 nM, and no binding affinity for the B1 receptor. FR167344 inhibits the B2 receptor-mediated phosphatidylinositol (PI) hydrolysis and produces a concentration-dependent rightward shift in the dose-response curve to bradykinin. This shift is accompanied by a progressive reduction of maximal response. Estimated pA2 values for the antagonism of bradykinin induced PI hydrolysis by FR167344 is 8.0. FR167344 shows no stimulatory effects on PI hydrolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 215258-13-2
-
Masse moléculaire 673.38
-
Formule C30H28BrCl2N5O4
-
SMILES
O=C(N(C)C)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=CC=CN4C3=NC(C)=C4Br)=C2Cl)C)=O)=O)C=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Aramori I, et al. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51(2):171-6. [Content Brief]
[2]. Asano M, et al. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivoanimal models of inflammation.Br J Pharmacol. 1997 Dec;122(7):1436-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR167344 free base Related Classifications
HY-100301 Related Classifications
Powered by Bioz