DBCO-PEG1000-FA
DBCO-PEG1000-FA (DBCO-PEG1000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications.
For research use only. We do not sell to patients.
- Molecular Weight:1000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DBCO-PEG-FA acts as a targeting guide molecule to direct europium-labeled MS2 virus-like particles to human nasopharyngeal carcinoma cells with high folate receptor expression, thereby enabling ultra-high sensitivity cancer cell counting detection[1].
DBCO-PEG-FA is used to modify a CRISPR-Cas9 gene biological nanoparticle to enhance its targeting ability and anti-tumor effect[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1000 (Average)
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SMILES
O=C(CCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)NCCOCCNC(CCC(C(O)=O)NC(C4=CC=C(C=C4)NCC5=NC6=C(C(O)=NC(N)=N6)N=C5)=O)=O.[n]
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Synonyms
DBCO-PEG1000-Folate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yuan R, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Anal Chem. 2019;91(8):4948-4952. [Content Brief]
[2]. Ren Y, et al. A Recombinant Targeted Bionanoparticle In Vitro Expressing a Gene-Editing Protein for Epidermal Growth Factor Receptor Mutant Lung Cancer. ACS Nano. 2026;20(6):4920-4941. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DBCO-PEG1000-FA Related Classifications
HY-W1123936B Related Classifications
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