FOLR4 Protein, Human (HEK293, His)

The FOLR4 protein serves as a receptor for IZUMO1 on the egg membrane and plays a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and FOLR4 (IZUMO1R/JUNO) is an important adhesion event that is required for fertilization but not sufficient for cell fusion. FOLR4 Protein, Human (HEK293, His) is the recombinant human-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR4 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of 30-35 kDa.

FOLR4 Protein functions as a receptor for IZUMO1 at the cell surface of oocytes (oolemma), playing a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and its receptor FOLR4, known as IZUMO1R/JUNO, is an essential adhesion event between sperm and egg, necessary for fertilization, although it alone is not sufficient for cell fusion. Contrary to its name, FOLR4 does not bind folate, and its ligand-receptor interaction is not classified as a membrane 'fusogen.' Existing as a monomer, FOLR4 directly interacts with IZUMO1, forming a complex with 1:1 stoichiometry. Interestingly, FCRL3/MAIA replaces IZUMO1R/JUNO as the receptor for IZUMO1 after sperm-egg adhesion, facilitating species-specific gamete fusion. These interactions highlight the intricate molecular mechanisms underlying gamete recognition and fusion during the fertilization process.

Human

HEK293

C-His

A6ND01-1 (G20-S228)

390243  [NCBI]

30-35 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.