IZUMO1R - IZUMO1 receptor, JUNO Gene

Also Known as JUNO; FOLR4; Folbp3; FR-delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 390243

About IZUMO1R

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,304,580-94,308,146 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Enables signaling receptor activity. Predicted to be involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in extracellular region and plasma membrane. Predicted to be anchored component of external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

IZUMO1R Products (2)

mRNA Protein Name
NM_001199206.4 NP_001186135.1 sperm-egg fusion protein Juno precursor
NM_001393610.1 NP_001380539.1 sperm-egg fusion protein Juno precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24739963 GOA
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
24739963 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IZUMO1R Protein Structure

Folate_rec

Folate_rec: Folate receptor family (26 - 201)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

sperm-egg fusion protein Juno

  • IZUMO1 receptor protein JUNO

Recombinant IZUMO1R Proteins

Cat. No. Product Name Accession Purity
HY-P77936 FOLR4 Protein, Human (HEK293, His) A6ND01-1 (G20-S228) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Subacute Leukemia
Biotin Deficiency

  • Biotin Deficiency Disease

  • B7 Deficiency

  • Biotan Vitamin Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07005 IZUMO1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21242 Izumo1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27759 Izumo1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IZUMO1R RGD RGD:1585174
Mus musculus IZUMO1R MGD MGI:1929185
Bos taurus IZUMO1R VGNC VGNC:106788
Felis catus IZUMO1R VGNC VGNC:62992
Canis familiaris IZUMO1R VGNC VGNC:59053
Macaca mulatta IZUMO1R VGNC VGNC:101294
Others IZUMO1R NCBI