FR179642
Based on 1 Customer Validation
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 168110-44-9
- Formula: C35H52N8O20S
- Molecular Weight:936.89
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FR179642 can be obtained through hydrolysis of FR901379, and utilized for synthesis of antifungal agent Micafungin (HY-17579)[1]. Micafungin inhibits the fungal cell wall synthesis through inhibition of β-(1,3)-D-glucan synthesis, thereby exhibiting antifungal activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 168110-44-9
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Appearance Solid
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Molecular Weight 936.89
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Formula C35H52N8O20S
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Color White to off-white
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SMILES
O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC(O[S](=O)(O)=O)=C3O)O)=O)([H])[C@H](O)CC(N)=O)N(C[C@@H]4C)[C@@](C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)N)O)O)=O)([H])[C@H]4O
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Structure Classification
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Initial Source
Coleophoma empetri
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 100 mg/mL (106.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (106.74 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Satoshi Ueda, et al. Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907. J Antibiot (Tokyo) [Content Brief]
[2]. M Tomishima, et al. FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity. J Antibiot (Tokyo) [Content Brief]
[3]. Jiang X, et al., A Hadal Streptomyces-Derived Echinocandin Acylase Discovered through the Prioritization of Protein Families. Mar Drugs. 2024 May 7;22(5):212. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0674 mL | 5.3368 mL | 10.6736 mL | 26.6840 mL |
| 5 mM | 0.2135 mL | 1.0674 mL | 2.1347 mL | 5.3368 mL | |
| 10 mM | 0.1067 mL | 0.5337 mL | 1.0674 mL | 2.6684 mL | |
| 15 mM | 0.0712 mL | 0.3558 mL | 0.7116 mL | 1.7789 mL | |
| 20 mM | 0.0534 mL | 0.2668 mL | 0.5337 mL | 1.3342 mL | |
| 25 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL | 1.0674 mL | |
| 30 mM | 0.0356 mL | 0.1779 mL | 0.3558 mL | 0.8895 mL | |
| 40 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6671 mL | |
| 50 mM | 0.0213 mL | 0.1067 mL | 0.2135 mL | 0.5337 mL | |
| 60 mM | 0.0178 mL | 0.0889 mL | 0.1779 mL | 0.4447 mL | |
| 80 mM | 0.0133 mL | 0.0667 mL | 0.1334 mL | 0.3336 mL | |
| 100 mM | 0.0107 mL | 0.0534 mL | 0.1067 mL | 0.2668 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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