2. Epigenetics
  3. SF3B1
  4. Sudemycin E

Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research.

For research use only. We do not sell to patients.

Sudemycin E

Sudemycin E Chemical Structure

CAS No. : 1197054-49-1

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Sudemycin E Related Antibodies

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Description

Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research[1].

Cellular Effect
Cell Line Type Value Description References
JeKo-1 IC50
150 nM
Compound: 26
Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
Cytotoxicity against human JeKo1 cells after 72 hrs by XTT assay
[PMID: 19877647]
JeKo-1 IC50
220 nM
Compound: 19p
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay
[PMID: 24325474]
Molecular Weight

491.62

Formula

C27H41NO7
CAS No.
SMILES

CC(C)C(O[C@@H](C)/C=C\C(N[C@@H](CO1)CO[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sudemycin E Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sudemycin E1197054-49-1SF3B1Splicing Factor 3b Subunit 1FR901464snRNPtumorcancerInhibitorinhibitorinhibit

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