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Results for "

antimalarial+agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (1) Aminopeptidase (1) AMPK (1) Antibiotic (7) Antifolate (3) Apoptosis (8) Autophagy (18) Bacterial (8) CaMK (2) Caspase (1) Clathrin (1) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Drug Intermediate (2) Drug Isomer (1) Drug Metabolite (9) Endogenous Metabolite (1) Enolase (1) Ephrin Receptor (1) Farnesyl Transferase (1) Ferroptosis (1) FLT3 (1) Fungal (4) Glucosylceramide Synthase (GCS) (1) Guanylate Cyclase (1) Haspin Kinase (1) Histone Methyltransferase (8) Isotope-Labeled Compounds (11) Mitochondrial Metabolism (1) Mitophagy (5) Na+/K+ ATPase (1) NF-κB (2) Nuclear Hormone Receptor 4A/NR4A (7) Nucleoside Antimetabolite/Analog (2) Paraptosis (1) Parasite (177) PI4K (3) Potassium Channel (8) Reactive Oxygen Species (ROS) (5) Reference Standards (20) ROS Kinase (4) SARS-CoV (13) Toll-like Receptor (TLR) (9)
By Research Areas:	Cancer (29) Cardiovascular Disease (5) Endocrinology (3) Infection (182) Inflammation/Immunology (20) Metabolic Disease (7) Neurological Disease (11)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1)

192

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-13735A

Quinacrine dihydrochloride 5+ Cited Publications Mepacrine dihydrochloride; SN-390 dihydrochloride	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable *antimalarial* agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis .

HY-112853

Fosmidomycin sodium salt 2 Publications Verification FR-31564	Bacterial Antibiotic	Infection
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.

HY-10852

Arterolane OZ 277; RBx 11160	Parasite	Infection
Arterolane is an antimalarial agent, with IC₅₀ of both 1.1 nM against P. falciparum Ro73 and W2, respectively.

HY-B1896B

Piperaquine tetraphosphate tetrahydrate 1 Publications Verification	Parasite	Infection
Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin .

HY-19364

Ferroquine 1 Publications Verification Ferrochloroquine; SSR97193	Parasite	Infection
Ferroquine (Ferrochloroquine), a ferrocenyl analogue of Chloroquine, is an antimalarial agent. Ferroquine shows parasiticidal effect on *Plasmodium* by inducing oxidative stress and the subsequent destruction of the membrane .

HY-145964

INE963	Parasite Haspin Kinase FLT3	Infection
INE963 is a potent and fast-acting blood-stage antimalarial agent, with an EC₅₀s of 3-6 nM. INE963 is potential for single-dose cures in uncomplicated malaria .

HY-13735B

Quinacrine hydrochloride hydrate 5+ Cited Publications Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an *antimalarial* agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis .

HY-59132

2-Amino-1-phenylethanol	Drug Intermediate	Others
2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists .

HY-B1896A

Piperaquine phosphate 1 Publications Verification	Parasite	Infection
Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Parasite Ferroptosis	Infection
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .

HY-W009109

Antimalarial agent 1	Parasite	Infection
Antimalarial agent 1 is a potent antimalarial agent .

HY-148429

Antimalarial agent 17	Parasite	Others
Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides .

HY-W391596

Pamaquine	Parasite	Infection Neurological Disease
Pamaquine is an 8-aminoquinoline antimalarial agent. Pamaquine has neurotoxicity and can damage specific neuro-anatomical structures, leading to deficits of neurologic function in Rhesus monkeys models .

HY-100358

AQ-13 dihydrochloride	Parasite	Infection
AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.

HY-135578

Artelinic acid	Parasite	Infection
Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .

HY-13833

Endochin	Parasite	Infection
Endochin is an *antimalarial* agent. Endochin inhibits T.gondii with an IC₅₀ of 0.003 nM. Endochin is also active against experimental toxoplasmosis .

HY-148177

Sutidiazine ZY-19489; MMV 253; AZ13721412	Parasite	Infection
Sutidiazine (ZY-19489) is an orally active and antimalarial agent. Sutidiazine inhibits parasitemia-induced infection. Sutidiazine shows short half-lives (approximately 7 h) and an exposure effect .

HY-B0806S

Proguanil-d6	Parasite	Infection
Proguanil-d₆ is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent.

HY-186054

Antimalarial agent 57	Parasite	Infection
Antimalarial agent 57 (308470) is a quinoline methanol derivative with antimalarial activity. Antimalarial agent 57 can be used in malaria research .

HY-17036

Naphthoquine phosphate	Parasite	Infection
Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of *P. falciparum* to Chloroquine .

HY-143409

Antimalarial agent 10	Parasite	Infection
Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC₅₀ values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is .

HY-123915

Antimalarial agent 20	Parasite	Infection
Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC₅₀ of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay .

HY-157892

Antimalarial agent 38	Parasite	Infection
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .

HY-186055

Antimalarial agent 58	Parasite	Infection
Antimalarial agent 58 is a diaminoquinoline methanol compound with weak in vitro activity against Plasmodium falciparum strain D6, and no activity against Plasmodium falciparum strains W2, C235 and C2A .

HY-B1896

Piperaquine	Parasite	Infection
Piperaquine is a bisquinoline *antimalarial* agent. Piperaquine can be used in antimalarial research in combination with Artemisinin .

HY-179118

Antimalarial agent 53	Parasite	Infection
Antimalarial agent 53 (compound 31) is an antimalarial agent. Antimalarial agent 53 blocks protein synthesis by inhibiting the cytoplasmic ribosomes of malaria parasites, exhibiting potent antimalarial activity (IC₅₀ = 3.9 nM) and good selectivity. Antimalarial agent 53 has no cross resistance and good safety. Antimalarial agent 53 can be used for research on malaria .

HY-159900

Antimalarial agent 46	Parasite	Infection
Antimalarial agent 46 (Compound 42a) is an antimalarial agent with antimalarial activity. Antimalarial agent 46 shows inhibitory activity against P. falciparum lines .

HY-168208

Antimalarial agent 45	Parasite	Infection
Antimalarial agent 45 (compound 8I) is a antimalarial agent and shows antiplasmodial activity the IC₅₀ of 0.21 μM. Antimalarial agent 45 can be used for study of malaria .

HY-149937

Antimalarial agent 24	Parasite	Infection
Antimalarial agent 24 (Compound 7) is an antimalarial agent in vitro. Antimalarial agent 24 inhibits P. falciparum W2 strain with an IC₅₀ of 0.81 μM. Antimalarial agent 24 displays a CC₅₀ higher than 200 μM against HepG2 cells .

HY-161170

Antimalarial agent 36	Parasite	Infection
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .

HY-174325

Antimalarial agent 50	Parasite	Infection Inflammation/Immunology
Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.

HY-119613

Clociguanil BRL 50216	Parasite Dihydrofolate reductase (DHFR)	Infection Cardiovascular Disease
Clociguanil (BRL 50216), a DHFR inhibitor (IC₅₀: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action .

HY-147198

Antimalarial agent 13	Parasite	Infection
Antimalarial agent 13 (Compound 1) is a potent *antimalarial* agent. Antimalarial agent 13 shows inhibition with EC₅₀ values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively .

HY-176223

Antimalarial agent 51	Parasite	Infection
Antimalarial agent 51 (Compound 2) is an orally active antimalarial compound. Antimalarial agent 51 blocks nutrient uptake by Plasmodium by inhibiting the plasmodium surface anion channel (PSAC). Antimalarial agent 51 significantly inhibits the growth of Plasmodium under nutrient-restricted conditions. Combination of antimalarial agent 51 with the residual transport inhibitor PRT-2 can enhance the antimalarial effect. Antimalarial agent 51 can be used in the study of malaria targeting the PSAC channel .

HY-169194

Antimalarial agent 44	Parasite	Infection
Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes .

HY-149938

Antimalarial agent 25	Parasite	Infection
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo .

HY-W585869

Amorphadiene	Parasite	Infection
Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .

HY-143487

Antimalarial agent 12	Parasite	Infection
Antimalarial agent 12 (compound R-3b) is a potent *antimalarial* agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .

HY-115905

Antimalarial agent 9	Parasite	Infection
Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC₅₀-0.14 μM) and MDR strain (IC₅₀-0.41 μM) with minimal cytotoxicity and high selectivity .

HY-151965

Antimalarial agent 18	Parasite	Infection
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC₅₀=50 nM) and A. baumanii (IC₅₀=390 nM) .

HY-173312

Antimalarial agent 49	Parasite	Infection
Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC₅₀: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection .

HY-136448

SJ000025081	Parasite	Infection
SJ000025081 is a dihydropyridine and acts as a potent *antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria* model infected with P. yoelii .

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent *antimalarial* agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-149939

Antimalarial agent 26	Parasite	Infection
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo .

HY-155688

Antimalarial agent 29	Parasite	Infection
Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-155689

Antimalarial agent 30	Parasite	Infection
Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-114197

Antimalarial agent 14	Mitochondrial Metabolism Parasite	Infection
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .

HY-149919

Antimalarial agent 23	Parasite	Infection
Antimalarial agent 23 is an *antimalarial* benzimidazole with IC₅₀s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin .

HY-149882

Antimalarial agent 27	Parasite	Infection
Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC₅₀=0.37 μM). Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC₅₀=0.11 μM) .

HY-175362

WEHI-326	Parasite	Infection
WEHI-326 is a potent antimalarial agent targeting Plasmodium falciparum ROM8 and CSC1 proteins (IC₅₀=0.006 μM). WEHI-326 is promising for research of malaria .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N0176

Dihydroartemisinin 40+ Cited Publications Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification	Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite
Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection .

HY-59132

2-Amino-1-phenylethanol	Structural Classification Productos naturales Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists .

HY-N0352

Tuberostemonine 1 Publications Verification	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Plants Disease Research Fields Source Classification	Parasite
Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Infection other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification	Parasite Ferroptosis
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .

HY-W585869

Amorphadiene	Microorganisms Terpenoids Sesquiterpenes Source Classification	Parasite
Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .

HY-N0352R

Tuberostemonine (Standard)	Alkaloids Structural Classification other families Pyrrole Alkaloids Plants Source Classification	Reference Standards Parasite
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine has a level of activity as a feeding deterrent .

HY-N16123

Chloranthalactone C	Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub Source Classification	Parasite
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Cardiovascular Disease Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Classification of Application Fields Rubiaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Source Classification	Parasite Apoptosis
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as *antimalarial* agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Productos naturales Rourea minor (Gaerth.) Leenh. Plants Connaraceae Source Classification	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-N15562

Batzelladine L	Alkaloids Other Alkaloids Marine natural products Sponge Source Classification	Parasite
Batzelladine L is a potent *Plasmodium falciparum* inhibitor (IC₅₀= 0.4 μM). Batzelladine L shows moderate cytotoxicity to HepG2 cells (CC₅₀= 14 μM) with antimalarial properties. Batzelladine L is promising for research of antimalarial agents .

HY-59132R

2-Amino-1-phenylethanol (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards Drug Intermediate
2-Amino-1-phenylethanol (Standard) is the analytical standard of 2-Amino-1-phenylethanol. This product is intended for research and analytical applications. 2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists.

HY-N13034

Diuvaretin	Structural Classification Monodora minor Engl. & Diels Phenols Polyphenols Plants Annonaceae Source Classification	Caspase Apoptosis Parasite
Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria .

HY-N18294

(R,R)-Polysphorin	Structural Classification Araceae Ketones, Aldehydes, Acids Rhaphidophora decursiva (Roxb.) Schott Plants Source Classification	Parasite
(R,R)-Polysphorin is a neolignan *antimalarial* agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells .

HY-N18878

Ambigol C	Structural Classification Monophenols Microorganisms Phenols Source Classification	Bacterial Endogenous Metabolite Parasite
Ambigol C is an ambigol, Antibacterial agent and *Antimalarial* agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections .

HY-N17550

25-Hydroperoxycycloart-23-en-3β-ol	Triterpenes Structural Classification Terpenoids Euphorbia esula L. Euphorbiaceae Plants Source Classification	Bacterial Parasite
25-Hydroperoxycycloart-23-en-3β-ol is an anticancer, antibacterial, and *antimalarial* agent. 25-Hydroperoxycycloart-23-en-3β-ol can be isolated from Blepharodon nitidum. 25-Hydroperoxycycloart-23-en-3β-ol exhibits anti-*Mycobacterium* *tuberculosis* and antileishmanial activities. 25-Hydroperoxycycloart-23-en-3β-ol shows significant cytotoxic activity against a panel of tumor cell lines (large cell lung cancer, melanoma, colon adenocarcinoma, chronic myelogenous leukemia) .

Cat. No.	Nombre del producto	Chemical Structure

HY-B0806S

Proguanil-d6
Proguanil-d₆ is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent.

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B1322AS

Amodiaquine-d10
Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-B0803S

Lumefantrine-d18
Lumefantrine-d₁₈ is the deuterium labeled Lumefantrine, which is an antimalarial agent.

HY-A0130S

Sulfalene-13C6
Sulfalene- ¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .

HY-B1896S

Piperaquine-d6
Piperaquine-d₆ is the deuterium labeled Piperaquine . Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin .

HY-118865S

Piperaquine-d6 tetraphosphate
Piperaquine-d₆ (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .

HY-100662S

Didesethyl chloroquine-d4
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant .

HY-B1322AS1

Amodiaquine-d10 hydrochloride
Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-W777545

4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4
4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d₄ is the deuterium labeled Hydroxychloroquine Impurity E (HY-131262). Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-N0176S6

Dihydroartemisinin-d

Dihydroartemisinin-d (Dihydroqinghaosu-d) is the deuterium labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.

Cat. No.	Nombre del producto		Classification

HY-152313

2-Bromoadenosine		Nucleoside Analogs Adenosine
2-Bromoadenosine, antimalarial agent is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

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