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Art. -Nr.: HY-181864

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Rac1-IN-6

Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC₅₀ = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC₅₀ = 236.6 nM).

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CAS. Nr.: 2310304-72-2
Formel: C₂₆H₃₂N₆O
Molecular Weight:444.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rac1-IN-6 Chemical Structure

CAS. Nr.: 2310304-72-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Plasmodium

76.0 (D10) nM (IC₅₀)

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In Vitro

Rac1-IN-6 (72 h) potently inhibits the growth of chloroquine-sensitive *Plasmodium falciparum* strain D10 (with an IC₅₀ of 76.0 ± 10.0 nM) and chloroquine-resistant *Plasmodium falciparum* strain W2 (with an IC₅₀ of 236.6 ± 60.4 nM)^[1].
Rac1-IN-6 (72 h) exhibits low cytotoxicity against HepG2 cells, with an IC₅₀ value of 3625.9 ± 47.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2310304-72-2
Molecular Weight 444.57
Formel C₂₆H₃₂N₆O
SMILES

CCN1C2=C(C=C(NC3=NC(NCCCN4CCOCC4)=NC(C)=C3)C=C2)C5=C1C=CC=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Parapini S, et al. Design, synthesis and biological evaluation of Rac1-targeting carbazole-pyrimidines as host-directed antimalarials. Eur J Med Chem. 2026;308:118690. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Rac1-IN-6

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Rac1-IN-6 Related Classifications

HY-181864 Related Classifications