Rac1-IN-6
Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM).
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- No. CAS: 2310304-72-2
- Fòrmula: C26H32N6O
- Peso molecular:444.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Plasmodium 76.0 (D10) nM (IC50) |
In Vitro
Rac1-IN-6 (72 h) potently inhibits the growth of chloroquine-sensitive *Plasmodium falciparum* strain D10 (with an IC50 of 76.0 ± 10.0 nM) and chloroquine-resistant *Plasmodium falciparum* strain W2 (with an IC50 of 236.6 ± 60.4 nM)[1].
Rac1-IN-6 (72 h) exhibits low cytotoxicity against HepG2 cells, with an IC50 value of 3625.9 ± 47.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2310304-72-2
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Peso molecular 444.57
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Fòrmula C26H32N6O
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SMILES
CCN1C2=C(C=C(NC3=NC(NCCCN4CCOCC4)=NC(C)=C3)C=C2)C5=C1C=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rac1-IN-6 Related Classifications
HY-181864 Related Classifications
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