Rac1-IN-6
Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM).
For research use only. We do not sell to patients.
- CAS No.: 2310304-72-2
- Formula: C26H32N6O
- Molecular Weight:444.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Plasmodium 76.0 (D10) nM (IC50) |
Rac1-IN-6 (72 h) potently inhibits the growth of chloroquine-sensitive *Plasmodium falciparum* strain D10 (with an IC50 of 76.0 ± 10.0 nM) and chloroquine-resistant *Plasmodium falciparum* strain W2 (with an IC50 of 236.6 ± 60.4 nM)[1].
Rac1-IN-6 (72 h) exhibits low cytotoxicity against HepG2 cells, with an IC50 value of 3625.9 ± 47.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2310304-72-2
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Molecular Weight 444.57
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Formula C26H32N6O
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SMILES
CCN1C2=C(C=C(NC3=NC(NCCCN4CCOCC4)=NC(C)=C3)C=C2)C5=C1C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rac1-IN-6 Related Classifications
HY-181864 Related Classifications
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