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United States

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Cat. No.: HY-170840

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Antimalarial agent 47

Antimalarial agent 47 (compound F14) is an antimalarial compound, with an IC₅₀ of 235 nM for the Plasmodium falciparum W2 strain.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₄ClF₂NO
Molecular Weight:309.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antimalarial agent 47 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Antimalarial agent 47 (compound F14) is an antimalarial compound, with an IC₅₀ of 235 nM for the Plasmodium falciparum W2 strain^[1].

All Parasite Isoforms :

Chemical Information

Molecular Weight 309.74
Formula C₁₆H₁₄ClF₂NO
SMILES

FC1(F)CCC(NC(C)=C(C2=CC=C(Cl)C=C2)C3=O)=C3C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ge S, et al. Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties. Eur J Med Chem. 2025 Feb 15;284:117228. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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