DXR-IN-2
DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR.
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- CAS No.: 2260608-07-7
- Formule: C10H12NO5P
- Masse moléculaire:257.18
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
DXR-IN-2 (Compound 11a) (0.10-100 μg/mL, 24 h) shows negligible cytotoxicity against HepG2, with an IC50 of >50 μM[1].
DXR-IN-2 (0.5 ng/mL-100 μg/mL, 3 days) inhibits Plasmodium falciparum 3D7 growth by inhibiting the MEP pathway via DXR[1].
DXR-IN-2 (1 μM) remains stable in mouse liver microsomes for more than 1 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2260608-07-7
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Masse moléculaire 257.18
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Formule C10H12NO5P
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SMILES
O=C(C1=CC=CC=C1)N(C/C=C/P(O)(O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DXR-IN-2 Related Classifications
HY-158818 Related Classifications
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