2260608-07-7
2260608-07-7
Chemical Structure
DXR-IN-2
- CAS No.: 2260608-07-7
- Formula:C10H12NO5P
- Molecular Weight:257.18
InChIKey: WRBGAVGCJQZOGA-XBXARRHUSA-N
SMILES: O=C(C1=CC=CC=C1)N(C/C=C/P(O)(O)=O)O
Biological Activity: DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR[1].
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DXR-IN-2 | DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR. | |||||||||||||||||||||
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References
Keywords
