1. Anti-infection
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Autophagy
    Membrane Transporter/Ion Channel
  2. Parasite
    SARS-CoV
    Reactive Oxygen Species
    Autophagy
    Potassium Channel
  3. Mefloquine hydrochloride

Mefloquine hydrochloride (Synonyms: Mefloquin hydrochloride)

Cat. No.: HY-17437A Purity: 99.96%
Handling Instructions

Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research.

For research use only. We do not sell to patients.

Mefloquine hydrochloride Chemical Structure

Mefloquine hydrochloride Chemical Structure

CAS No. : 51773-92-3

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
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Estimated Time of Arrival: December 31
500 mg USD 119 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].

In Vitro

Mefloquine hydrochloride selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine hydrochloride also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation[2].
Mefloquine hydrochloride (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells[2].
Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mefloquine hydrochloride (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young 3.5-month-old and old 21-month-old female C57BL/6 mice[4]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; 14 days
Result: Reversed the lower vertebral cancellous bone volume and bone formation in old mice.
Clinical Trial
Molecular Weight

414.77

Formula

C₁₇H₁₇ClF₆N₂O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (241.10 mM)

H2O : 2.86 mg/mL (6.90 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4110 mL 12.0549 mL 24.1097 mL
5 mM 0.4822 mL 2.4110 mL 4.8219 mL
10 mM 0.2411 mL 1.2055 mL 2.4110 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Product Name:
Mefloquine hydrochloride
Cat. No.:
HY-17437A
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