1. Anti-infection
    Autophagy
  2. Parasite
    Autophagy
  3. Mefloquine hydrochloride

Mefloquine hydrochloride (Synonyms: Mefloquin hydrochloride)

Cat. No.: HY-17437A Purity: 99.96%
Handling Instructions

Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine.

For research use only. We do not sell to patients.

Mefloquine hydrochloride Chemical Structure

Mefloquine hydrochloride Chemical Structure

CAS No. : 51773-92-3

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10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
100 mg USD 66 In-stock
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500 mg USD 119 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. IC50 Value: 1 microM ( for K+ channel) [1] Target: Antiparasitic Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. MQ can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to kill cancer cells [2]. in vitro: Mefloquine inhibitedKvLQT1/minK channel currents with an IC50 value of approximately 1 microM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones. HERG channel currents were about 6-fold less sensitive to block by mefloquine (IC50 = 5.6 microM). Block of HERG displayed a positive voltage dependence with maximal inhibition obtained at more depolarized potentials [1]. MQ has a highly selective cytotoxicity that inhibits PCa cell growth. MQ-mediated ROS simultaneously downregulated Akt phosphorylation and activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and adenosine monophosphate-activated protein kinase (AMPK) signaling in PC3 cells [2]. in vivo: Pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9-11 post coitum (pc). The dams were euthanized on day 12 pc and gestational and embryos histological parameters were evaluated [3]. Clinical trial: Activity of Mefloquine Against Urinary Schistosomiasis . Phase 2

Clinical Trial
Molecular Weight

414.77

Formula

C₁₇H₁₇ClF₆N₂O

CAS No.

51773-92-3

SMILES

O[[email protected]]([[email protected]]1([H])NCCCC1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (241.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4110 mL 12.0549 mL 24.1097 mL
5 mM 0.4822 mL 2.4110 mL 4.8219 mL
10 mM 0.2411 mL 1.2055 mL 2.4110 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Keywords:

MefloquineMefloquinParasiteAutophagyInhibitorinhibitorinhibit

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Mefloquine hydrochloride
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