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  3. MMV008138

MMV008138 

Cat. No.: HY-123561 Purity: 98.00%
Handling Instructions

MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM.

For research use only. We do not sell to patients.

MMV008138 Chemical Structure

MMV008138 Chemical Structure

CAS No. : 1679333-73-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM[1][2].

IC50 & Target

IC50: 44 nM (PfIspD)[1]

In Vitro

MMV008138 targets the enzyme IspD in the MEP pathway of P. falciparum[1].
MMV008138 does not target human IspD[1].

Molecular Weight

361.22

Formula

C₁₈H₁₄Cl₂N₂O₂

CAS No.

1679333-73-3

SMILES

O=C([[email protected]@H]1CC2=C([[email protected]@H](C3=CC=C(Cl)C=C3Cl)N1)NC4=C2C=CC=C4)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (346.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7684 mL 13.8420 mL 27.6840 mL
5 mM 0.5537 mL 2.7684 mL 5.5368 mL
10 mM 0.2768 mL 1.3842 mL 2.7684 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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MMV008138
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HY-123561
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