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Art. -Nr.: HY-171215

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ML901

ML901 is a reaction-hijacking PfTyrRS inhibitor that blocks ATP consumption and translation. ML901 inhibits PfYRS by forming a covalent Tyr-ML901 adduct and blocking tRNA tyrosylation. ML901 inhibits Atg7-mediated GABARAP activation/transthioesterification and E1 ubiquitin-like activating enzyme activity. ML901 can be used for research on P. falciparum malaria.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2226228-02-8
Formel: C₁₁H₁₄F₂N₆O₇S
Molecular Weight:412.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

ML901 Chemical Structure

CAS. Nr.: 2226228-02-8

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[2]^[3]

PfYRS

Atg7

33 nM (IC₅₀)

UAE

5.39 μM (IC₅₀)

NAE

28 μM (IC₅₀)

GABARAP

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1650	EC₅₀	10.02 μM Compound: 4	Antiproliferative activity against human H1650 cells assessed as reduction in cell viability after 72 hrs by cell titer glow assay Antiproliferative activity against human H1650 cells assessed as reduction in cell viability after 72 hrs by cell titer glow assay	[PMID: 32912429]

In Vitro

Anti-cancerAutophagyLysosomal MetabolismParasitic InfectionProtein/Amino Acid Metabolism

Anti-cancer

ML901 inhibits HepG2 cell growth, with a 72 h IC₅₀ of 4650 nM^[1].

Autophagy

ML901 inhibits human Atg7 (IC₅₀ 0.033 µM), UAE (IC₅₀ 5.39 µM), and NAE (IC₅₀ 28.0 µM), with no inhibitory effect on SAE at ≤100 µM^[1].

Autophagy

Lysosomal Metabolism

ML901 inhibits human Atg7 with IC₅₀ = 33 nM, while showing weaker activity against other E1 enzymes^[2].

Parasitic Infection

ML901 inhibits the asexual blood-stage growth of Plasmodium falciparum 3D7 with a 72 h IC₅₀ of 2.8 nM, and exhibits a 6 h pulse IC₅₀ of 135 nM against Cam3.II^rev trophozoites^[1].

Parasitic Infection

Protein/Amino Acid Metabolism

ML901 inhibits ATP consumption of recombinant PfTyrRS in the presence of cognate tRNA^Tyr, with an IC₅₀ of 13.4 µM^[1].
ML901 (200 nM; 3 h) activates the amino acid starvation/eIF2α phosphorylation pathway in Plasmodium falciparum through an aaRS-related mechanism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

ML901 (50 mg/kg; i.p.; single dose) reduces P. falciparum parasitemia to baseline in human RBC-engrafted SCID mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (engrafted with human RBCs)^[2]
Dosage:

50 mg/kg
Administration:

i.p.; single dose
Result:

A single 50 mg/kg i.p. dose reduced parasitemia to baseline.

Chemical Information

CAS. Nr. 2226228-02-8
Molecular Weight 412.33
Formel C₁₁H₁₄F₂N₆O₇S
SMILES

O[C@@H]1[C@H](O)[C@@H](COS(N)(=O)=O)O[C@H]1N2C3=NC=NC(N)=C3C(OC(F)F)=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Stanley C, et al. A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLoS Pathog. 2024 Dec 9;20(12):e1012429.

[2]. Xie SC, et al. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.). 2022 Jun 03;376(6597):1074-1079. [Content Brief]

[3]. Xie SC, et al. Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development. Annu Rev Microbiol. 2023 Sep 15;77:111-129. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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ML901

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