2226228-02-8
2226228-02-8
Chemical Structure
ML901
- CAS No.: 2226228-02-8
- Formula:C11H14F2N6O7S
- Molecular Weight:412.33
InChIKey: DCMDVFZIMQIMKS-BHBWVORQSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COS(N)(=O)=O)O[C@H]1N2C3=NC=NC(N)=C3C(OC(F)F)=N2
Biological Activity: ML901 is an antimalarial agent with an IC50 value of 2 nM against the malaria parasite. ML901 specifically inhibits the tyrosine tRNA synthetase of the malaria parasite (PfYRS) through "receptor hijacking". ML901 exhibits full life-cycle killing activity in the malaria mouse model. ML901 can be used for studying malaria parasite infection[1].
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ML901 | ML901 is an antimalarial agent with an IC50 value of 2 nM against the malaria parasite. ML901 specifically inhibits the tyrosine tRNA synthetase of the malaria parasite (PfYRS) through "receptor hijacking". ML901 exhibits full life-cycle killing activity in the malaria mouse model. ML901 can be used for studying malaria parasite infection. | |||||||||||||||||||||
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References
Keywords
