Antimalarial agent 18
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM).
For research use only. We do not sell to patients.
- CAS No.: 3037689-82-7
- Formula: C23H44NO9P
- Molecular Weight:509.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MRC5 | CC50 |
40.3 μM
Compound: 13j
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
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[PMID: 36399924] |
In Vitro
Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC50 value of 40.3 μM[1].
Antimalarial agent 18 poorly inhibits avirulent M. tuberculosis strain (H37Ra) with an IC50 value >64 μM[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, and A. baumannii in particular[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3037689-82-7
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Molecular Weight 509.57
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Formula C23H44NO9P
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SMILES
CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 18 Related Classifications
HY-151965 Related Classifications
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