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  3. Antimalarial agent 18

Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM).

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Antimalarial agent 18 Chemical Structure

Antimalarial agent 18 Chemical Structure

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Description

Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM)[1].

IC50 & Target

Plasmodium

 

In Vitro

Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC50 value of 40.3 μM[1].
Antimalarial agent 18 poorly inhibits avirulent M. tuberculosis strain (H37Ra) with an IC50 value >64 μM[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, and A. baumannii in particular[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

509.57

Formula

C23H44NO9P

SMILES

CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antimalarial agent 18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antimalarial agent 18
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HY-151965
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