3037689-82-7
Chemical Structure
Antimalarial agent 18
- CAS No.: 3037689-82-7
- Formula:C23H44NO9P
- Molecular Weight:509.57
IUPAC Name: (3S)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-((8-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidine-3-carboxamido)octyl)oxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
InChIKey: JKGXSVCXJVTQCR-UHFFFAOYSA-N
SMILES: CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O
Biological Activity: Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM)[1].
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Antimalarial agent 18 | Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM). | |||||||||||||||||||||
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Keywords
