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  3. Parasite
  4. Antimalarial agent 56

Antimalarial agent 56 is an orally active antimalarial agent. Antimalarial agent 56 inhibits the growth of both drug-sensitive and drug-resistant Plasmodium falciparum strains in vitro. Antimalarial agent 56 can be used in malaria research.

For research use only. We do not sell to patients.

Antimalarial agent 56

Antimalarial agent 56 Chemical Structure

CAS No. : 1220533-66-3

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Antimalarial agent 56 Related Antibodies

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Description

Antimalarial agent 56 is an orally active antimalarial agent. Antimalarial agent 56 inhibits the growth of both drug-sensitive and drug-resistant Plasmodium falciparum strains in vitro. Antimalarial agent 56 can be used in malaria research[1].

In Vitro

Antimalarial agent 56 (WR319535) inhibits the growth of Plasmodium falciparum strains W2, D6, C235, and C2A with IC90 values ranging from 75 to 275 ng/mL, and has a macrophage cytotoxicity LC50 of 4110 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 56 Related Antibodies
In Vivo

Antimalarial agent 56 (WR319535) (160 mg/kg; p.o.; daily; 3 consecutive days) produces a 7-day delay in mortality in Plasmodium berghei-infected ICR mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 160 mg/kg
Administration: p.o.; daily; 3 consecutive days
Result: Produced a 7-day delay in mortality relative to vehicle control.
Molecular Weight

433.39

Formula

C20H21F6N3O
CAS No.
SMILES

FC(F)(C1=NC2=C(C(C(CNCC34CNC(C4)CC3)O)=C1)C=CC=C2C(F)(F)F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Antimalarial agent 56 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 561220533-66-3Antimalarial agent56Antimalarial agent-56ParasitePlasmodium falciparumD6 strainC235 strainmacrophageMDR1-transfected MDCK cell monolayersmalariaICR mousePlasmodium bergheiC2A strainW2 strainInhibitorinhibitorinhibit

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