2. Anti-infection
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  4. Isopentaquine

Isopentaquine is an orally active antimalarial agent. Isopentaquine induces mild morphological changes in the exoerythrocytic stage of Plasmodium fallax, with a ED50 of 6.7 mg/L. Isopentaquine causes degenerative changes in the development of Plasmodium oocysts in infected mosquitoes. Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes. Isopentaquine impairs sympathetic cardiovascular reflexes. Isopentaquine decreases the recurrence rate and total disease duration of Plasmodium vivax infection. Isopentaquine can be used in malaria-related research.

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Isopentaquine

Isopentaquine Chemical Structure

CAS No. : 529-73-7

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Isopentaquine Related Antibodies

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Description

Isopentaquine is an orally active antimalarial agent. Isopentaquine induces mild morphological changes in the exoerythrocytic stage of Plasmodium fallax, with a ED50 of 6.7 mg/L. Isopentaquine causes degenerative changes in the development of Plasmodium oocysts in infected mosquitoes. Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes. Isopentaquine impairs sympathetic cardiovascular reflexes. Isopentaquine decreases the recurrence rate and total disease duration of Plasmodium vivax infection. Isopentaquine can be used in malaria-related research[1][2][3].

IC50 & Target[1]

Plasmodium

 

In Vitro

Isopentaquine (10-20 mg/L; 48 h) induces mild morphological changes in exoerythrocytic stages of Plasmodium fallax grown in embryonic turkey brain cells, with an ED50 of 6.7 mg/l, making it less effective than other tested 8-aminoquinolines[1].
Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isopentaquine Related Antibodies
In Vivo

Isopentaquine (0.02% concentration; oral; via feeding) causes degenerative changes in Plasmodium falciparum oocyst development in infected mosquitoes[2].
Isopentaquine (Large doses; prolonged period) impairs sympathetic cardiovascular reflexes in dogs and monkeys via medullary cell group destruction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain[2]
Dosage: 0.02% concentration
Administration: oral; via feeding
Result: Produced degenerative changes in Plasmodium falciparum oocyst development in infected mosquitoes.
Animal Model: unspecified strains[2]
Dosage: Large doses
Administration: prolonged period
Result: Impaired sympathetic cardiovascular reflexes in dogs and monkeys, believed to be due to destruction of medullary cell groups.
Molecular Weight

301.43

Formula

C18H27N3O
CAS No.
SMILES

N=1C=CC=C2C=C(OC)C=C(NC(C)CCCNC(C)C)C12
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Purity & Documentation
References
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Isopentaquine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isopentaquine529-73-7Parasiteembryonic turkey brain cell culturemosquitoesPlasmodium falciparumoocystmonkeysgametocytesexoerythrocytic stagesdogsPlasmodium fallaxPlasmodium vivaxInhibitorinhibitorinhibit

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