Isopentaquine
Isopentaquine is an orally active antimalarial agent. Isopentaquine induces mild morphological changes in the exoerythrocytic stage of Plasmodium fallax, with a ED50 of 6.7 mg/L. Isopentaquine causes degenerative changes in the development of Plasmodium oocysts in infected mosquitoes. Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes. Isopentaquine impairs sympathetic cardiovascular reflexes. Isopentaquine decreases the recurrence rate and total disease duration of Plasmodium vivax infection. Isopentaquine can be used in malaria-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 529-73-7
- 分子式: C18H27N3O
- 分子量:301.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
14.4 μM
Compound: 19g, SID 24724375
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Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
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[PMID: 18571929] |
Isopentaquine (10-20 mg/L; 48 h) induces mild morphological changes in exoerythrocytic stages of Plasmodium fallax grown in embryonic turkey brain cells, with an ED50 of 6.7 mg/l, making it less effective than other tested 8-aminoquinolines[1].
Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isopentaquine (Large doses; prolonged period) impairs sympathetic cardiovascular reflexes in dogs and monkeys via medullary cell group destruction[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain[2]
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Dosage:0.02% concentration
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Administration:oral; via feeding
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Result:Produced degenerative changes in Plasmodium falciparum oocyst development in infected mosquitoes.
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Animal Model:unspecified strains[2]
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Dosage:Large doses
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Administration:prolonged period
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Result:Impaired sympathetic cardiovascular reflexes in dogs and monkeys, believed to be due to destruction of medullary cell groups.
化学情報
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CAS 番号 529-73-7
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分子量 301.43
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分子式 C18H27N3O
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SMILES
N=1C=CC=C2C=C(OC)C=C(NC(C)CCCNC(C)C)C12
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Aikawa M, et al. Morphological effects of 8-aminoquinolines on the exoerythrocytic stages of Plasmodium fallax. Mil Med. 1969 Sep;134(10):986-99. [Content Brief]
[2]. Grewal RS. Pharmacology of 8-aminoquinolines. Bull World Health Organ. 1981;59(3):397-406. [Content Brief]
[3]. van der Meer JW, et al. Abstract!. Neth J Med. 2002;60(11):418. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isopentaquine 関連分類
HY-119511 関連分類
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