Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling
- Bioorg Med Chem. 2008 Jul 15;16(14):6903-10. doi: 10.1016/j.bmc.2008.05.047.
- 1. Chemical Biology Discovery Center, 1510 Clifton Road, Emory University, Atlanta, GA 30322, USA.
The molecular chaperone HSP90 plays important roles in maintaining malignant phenotypes. Recent studies suggest that HSP90 exerts high-affinity interactions with multiple oncoproteins, which are essential for the growth of tumor cells. As a result, research has focused on finding HSP90 probes as potential and selective Anticancer agents. In a high-throughput screening exercise, we identified quinoline 7 as a moderate inhibitor of HSP90. Further hit identification, SAR studies, and biological investigation revealed several synthetic analogs in this series with micromolar activities in both fluorescent polarization (FP) assay and a cell-based Western blot (WB) assay. These compounds represent a new class of HSP90 inhibitors with simple chemical structures.