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Cat. No.: HY-161170

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Antimalarial agent 36

Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2.

For research use only. We do not sell to patients.

CAS No.: 2982633-03-2
Formula: C₃₁H₂₉ClF₃N₅O₂S
Molecular Weight:628.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antimalarial agent 36 Chemical Structure

CAS No.: 2982633-03-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	2590 nM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38214254]
MCF7	EC₅₀	3510 nM Compound: 1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38214254]

Chemical Information

CAS No. 2982633-03-2
Molecular Weight 628.11
Formula C₃₁H₂₉ClF₃N₅O₂S
SMILES

O=C(C1=CC(C2=CC=CS2)=CN=C1)NC3=CC(Cl)=CC(C(NC4=CC=C(C(C(F)(F)F)=C4)CN5CCN(CC5)CC)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang L, et al. Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 25;67(2):1460-1480. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Antimalarial agent 36

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antimalarial agent 36 Related Classifications

HY-161170 Related Classifications