Antimalarial agent 38

Cat. No.: HY-157892: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model.

For research use only. We do not sell to patients.

Antimalarial agent 38 Chemical Structure

CAS No. : 123580-46-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

View All Isoforms

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	> 20 μM Compound: 29	Ability to potentiate DOX cytotoxicity on K562/DOX MDR cells. Cell survival was assayed by MTT conversion Ability to potentiate DOX cytotoxicity on K562/DOX MDR cells. Cell survival was assayed by MTT conversion	[PMID: 9986718]
MRC5	IC₅₀	> 70 μM Compound: 1	Cytotoxicity against MRC5 cells Cytotoxicity against MRC5 cells	[PMID: 17166718]

In Vivo

Antimalarial agent 38 (Compound 1) (10-50 mg/kg; p.o; daily; 4 days) shows active in Plasmodium yoelii nigeriensis infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Plasmodium yoelii nigeriensis N67 infected mice ^[1]
Dosage:	10 mg/kg, 50 mg/kg
Administration:	p.o; daily; 4 days
Result:	Showed dose-dependent reduction of parasitemia (around 40% of parasite growth inhibition at 50 mg/kg/day).

Molecular Weight

692.71

Formula

C₃₆H₄₀N₂O₁₂

CAS No.

123580-46-1

Appearance

Solid

SMILES

O=C(COC1=C(OC)C=CC(C(OC2=C3C(O)=CC(OCC(N4CCN(CC4)CC5=CC=C(C(OC)=C5OC)OC)=O)=C2)=CC3=O)=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (144.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4436 mL	7.2180 mL	14.4361 mL
5 mM	0.2887 mL	1.4436 mL	2.8872 mL
10 mM	0.1444 mL	0.7218 mL	1.4436 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Data Sheet (269 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Auffret G, et al., Synthesis and antimalarial evaluation of a series of piperazinyl flavones. Bioorg Med Chem Lett. 2007 Feb 15;17(4):959-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4436 mL	7.2180 mL	14.4361 mL	36.0901 mL
	5 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2180 mL
	10 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	15 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	20 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	25 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	30 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	40 mM	0.0361 mL	0.1805 mL	0.3609 mL	0.9023 mL
	50 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL
	60 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL
	80 mM	0.0180 mL	0.0902 mL	0.1805 mL	0.4511 mL
	100 mM	0.0144 mL	0.0722 mL	0.1444 mL	0.3609 mL