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Art. -Nr.: HY-148269

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AN13762

AN13762 is a benzoxaborole antimalarial agent. AN13762 augments Plasmodium falciparum stress responses. AN13762 acts against cultured and fresh Plasmodium falciparum isolates and in vivo murine malaria models. AN13762 can be used for the research of malaria.

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CAS. Nr.: 2025371-99-5
Formel: C₁₇H₁₈BN₃O₅
Molecular Weight:355.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AN13762 Chemical Structure

CAS. Nr.: 2025371-99-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

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In Vitro

AN13762 (1 nM-10 μM; 48 h) potently inhibits the growth of Plasmodium falciparum laboratory strains (3D7, W2, Dd2, 7G8, VS1, K1, D6) with IC₅₀ values ranging from 18 nM to 118 nM^[1].
AN13762 (72 h) potently inhibits the growth of fresh Plasmodium falciparum clinical isolates from Uganda^[1].
AN13762 (500 nM; 8 h) exhibits the greatest antimalarial activity against ring- and trophozoite-stage Plasmodium falciparum Dd2 parasites, causing abnormal trophozoite morphology and preventing further development^[1].
AN13762 produces low-level resistant Plasmodium falciparum (Dd2, 3D7, W2) with PfPARE mutations (IC₅₀ = 180-1340 nM) and high-level resistant parasites with additional ubiquitination/sumoylation or PfCPSF3 mutations (IC₅₀ = 1.1-5.0 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2025371-99-5
Molecular Weight 355.15
Formel C₁₇H₁₈BN₃O₅
SMILES

O=C(N1CC(C)(C1)O)C2=CN=C(OC3=CC=C4C(B(OC4)O)=C3C)C=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sindhe KMV, et al. Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020;11(1):e02640-19. Published 2020 Jan 28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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AN13762

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