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Cat. No.: HY-161384

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WJM-715

WJM-715 is an antimalarial agent with an EC₅₀ of 0.015 μM by trageting STAR-related lipid transfer protein (PfSTART1) with a K_D of 14 nM.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₂Cl₂N₄O₄S
Molecular Weight:473.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

WJM-715 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

WJM-715 is an antimalarial agent with an EC₅₀ of 0.015 μM by trageting STAR-related lipid transfer protein (PfSTART1) with a K_D of 14 nM^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	>40 μM Compound: 19b; WJM-715	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by Cell Titer-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by Cell Titer-Glo assay	[PMID: 38554474]

In Vitro

WJM-715 improves the aqueous solubility at pH 7.4 to 60 μM and the metabolic stability in rats hepatocytes to 68 μL/min/10⁶cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WJM-715 (50 mg/kg, p.o.) reveals a pharmacokinetic evaluation with a half-time of 5.9 hours in swiss outbred mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 473.37
Formula C₁₉H₂₂Cl₂N₄O₄S
SMILES

O=S(N1CCOCC1)(C2=C(Cl)C=CC(NC(C)(C)C(NC3=CN=CC(Cl)=C3)=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nguyen W, et al., Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein. Eur J Med Chem. 2024 Mar 25;270:116354. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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