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Cat. No.: HY-119707

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TDR 32750

TDR 32750 is an antimalarial agent. TDR 32750 inhibits P. falciparum activity with an ED₅₀ value of 0.014 μM.

For research use only. We do not sell to patients.

CAS No.: 1428183-45-2
Formula: C₂₂H₂₁F₃N₂O₃
Molecular Weight:418.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TDR 32750 Chemical Structure

CAS No.: 1428183-45-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TDR 32750 is an antimalarial agent. TDR 32750 inhibits P. falciparum activity with an ED₅₀ value of 0.014 μM^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>10 μM Compound: GNF-Pf-1753	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
L6	EC₅₀	15 μM Compound: 8a, TDR32750	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23517371]

Chemical Information

CAS No. 1428183-45-2
Molecular Weight 418.41
Formula C₂₂H₂₁F₃N₂O₃
SMILES

O=C(OCC)C(C1=O)=C(N/C1=C/C2=C(N(C(C)=C2)C3=CC=CC=C3C(F)(F)F)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dinakaran Murugesan, et al. Structure-activity relationship studies of pyrrolone antimalarial agents. ChemMedChem. 2013 Sep;8(9):1537-44. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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TDR 32750

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TDR 32750 Related Classifications

HY-119707 Related Classifications