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  4. Antimalarial agent 59

Antimalarial agent 59 is an antimalarial agent. Antimalarial agent 59 inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM. Antimalarial agent 59 also shows cytotoxic activity against cancer cells. Antimalarial agent 59 can be used for the researches of malaria and ovarian cancer.

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Antimalarial agent 59

Antimalarial agent 59 Chemical Structure

CAS No. : 3103602-12-3

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Antimalarial agent 59 Related Antibodies

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Description

Antimalarial agent 59 is an antimalarial agent. Antimalarial agent 59 inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM. Antimalarial agent 59 also shows cytotoxic activity against cancer cells. Antimalarial agent 59 can be used for the researches of malaria and ovarian cancer[1].

In Vitro

Antimalarial agent 59 (Compound 5i) (48 h) potently inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM and a selectivity index of 232[1].
Antimalarial agent 59 (72 h) inhibits the growth of HeLa cervical cancer cells with an LD50 of 10.85 μM[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A2780 ovarian cancer cell viability in a concentration- and time-dependent manner, with near-complete inhibition at 10 μM after 48 and 72 h[1].
Antimalarial agent 59 (1-10 μM; 72 h) inhibits the growth of A2780 ovarian cancer cells with an IC50 of 3.82 ± 1.38 μM after 72 h of incubation[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A549 lung adenocarcinoma cell viability in a concentration- and time-dependent manner, with the strongest inhibition (15.75% viability) observed at 10 μM after 72 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 59 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A2780 ovarian cancer cells
Concentration: 1, 10 μM
Incubation Time: 24, 48, 72 h
Result: Reduced cell viability to 67.38% at 1 μM (24 h).
Reduced cell viability to 79.57% at 1 μM (48 h).
Reduced cell viability to 92.20% at 1 μM (72 h).
Reduced cell viability to 2.19% at 10 μM (24 h).
Reduced cell viability to 0.04% at 10 μM (48 h).
Reduced cell viability to 1.03% at 10 μM (72 h).

Cell Cytotoxicity Assay[1]

Cell Line: A549 lung adenocarcinoma cells
Concentration: 1, 10 μM
Incubation Time: 24, 48, 72 h
Result: Reduced cell viability to 99.03% at 1 μM (24 h).
Reduced cell viability to 92.09% at 1 μM (48 h).
Reduced cell viability to 97.16% at 1 μM (72 h).
Reduced cell viability to 32.81% at 10 μM (24 h).
Reduced cell viability to 19.87% at 10 μM (48 h).
Reduced cell viability to 15.75% at 10 μM (72 h).
Molecular Weight

340.37

Formula

C17H24O7
CAS No.
SMILES

COC1=CC=C(C2OOC3(CCC(C)CC3)OO2)C(OC)=C1OC
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References
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Antimalarial agent 59 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 593103602-12-3Antimalarial agent59Antimalarial agent-59ParasitemalariaA549 lung adenocarcinoma cellsovarian cancer cellsPlasmodium falciparumHeLa cervical cancer cellsA2780 ovarian cancer cellschloroquine-resistant FcB1 straincervical cancer cellsovarian cancerInhibitorinhibitorinhibit

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