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Results for "

AChE+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Amyloid-β (11) Antibiotic (1) Apoptosis (6) Autophagy (1) Bacterial (6) Bcl-2 Family (1) Beta-secretase (1) Carbonic Anhydrase (1) Caspase (2) CCR (1) Cholinesterase (ChE) (227) COX (2) Dengue Virus (3) Dopamine Receptor (4) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (4) Endogenous Metabolite (3) Enterovirus (2) Environmental Pollutants (9) ERK (4) Flavivirus (3) Fungal (1) GABA Receptor (1) GSK-3 (2) Heme Oxygenase (HO) (1) iGluR (4) Insecticide (15) Interleukin Related (3) Isotope-Labeled Compounds (18) JNK (2) Keap1-Nrf2 (7) Lactate Dehydrogenase (1) LOX-1 (1) mAChR (3) MMP (4) Monoamine Oxidase (4) nAChR (4) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (1) Opioid Receptor (3) P-glycoprotein (5) p38 MAPK (2) Parasite (14) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (10) Reference Standards (33) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (1) Infection (25) Inflammation/Immunology (26) Metabolic Disease (10) Neurological Disease (191)

By Targets:

5-HT Receptor (3)

Amyloid-β (11)

Antibiotic (1)

Apoptosis (6)

Autophagy (1)

Bacterial (6)

Bcl-2 Family (1)

Beta-secretase (1)

Carbonic Anhydrase (1)

Caspase (2)

CCR (1)

Cholinesterase (ChE) (227)

COX (2)

Dengue Virus (3)

Dopamine Receptor (4)

Drug Derivative (2)

Drug Intermediate (1)

Drug Metabolite (4)

Endogenous Metabolite (3)

Enterovirus (2)

Environmental Pollutants (9)

ERK (4)

Flavivirus (3)

Fungal (1)

GABA Receptor (1)

GSK-3 (2)

Heme Oxygenase (HO) (1)

iGluR (4)

Insecticide (15)

Interleukin Related (3)

Isotope-Labeled Compounds (18)

JNK (2)

Keap1-Nrf2 (7)

Lactate Dehydrogenase (1)

LOX-1 (1)

mAChR (3)

MMP (4)

Monoamine Oxidase (4)

nAChR (4)

NF-κB (1)

NO Synthase (2)

NOD-like Receptor (NLR) (1)

Opioid Receptor (3)

P-glycoprotein (5)

p38 MAPK (2)

Parasite (14)

Phosphodiesterase (PDE) (1)

Reactive Oxygen Species (ROS) (10)

Reference Standards (33)

STAT (1)

TNF Receptor (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (1)

Infection (25)

Inflammation/Immunology (26)

Metabolic Disease (10)

Neurological Disease (191)

236

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14566

Donepezil Maximum Cited Publications 24 Publications Verification E2020 free base	Cholinesterase (ChE)	Neurological Disease Cancer
Donepezil (E2020 free base) is a specific and potent *AChE* inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-B0034

Donepezil Hydrochloride Maximum Cited Publications 24 Publications Verification E2020	Cholinesterase (ChE)	Neurological Disease Cancer
Donepezil Hydrochloride (E2020) is a reversible, selective *AChE* inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-76299

Galanthamine Maximum Cited Publications 15 Publications Verification Galantamine	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-W017423

(-)-Carvone	Environmental Pollutants Cholinesterase (ChE)	Neurological Disease
(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Cholinesterase (ChE) Endogenous Metabolite Parasite	Infection Neurological Disease Inflammation/Immunology
Coumaran (2,3-Dihydrobenzofuran) is an *AChE* inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-B0832

Profenofos 1 Publications Verification	Environmental Pollutants Cholinesterase (ChE) Insecticide	Neurological Disease
Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-N4261

Dehydronuciferine	Cholinesterase (ChE)	Metabolic Disease
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-76299R

Galanthamine (Standard) Galantamine (Standard)	Reference Standards Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-116792

Phenoxyacetone Phenoxy-2-propanone	Cholinesterase (ChE)	Others
Phenoxyacetone is a competitive acetylcholinesterase (AChE) inhibitor .

HY-I0020

Galanthaminone (-)-Narwedine; Narwedin	Cholinesterase (ChE)	Neurological Disease
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

HY-126765

Territrem B	Cholinesterase (ChE)	Infection Neurological Disease
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .

HY-N2211

Picfeltarraenin IB	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation .

HY-W009431

AChE-IN-84	Cholinesterase (ChE)	Neurological Disease
AChE-IN-84 (compound 21) is an *AChE* inhibitor .

HY-136838

(R)-Donepezil (R)-E2020 free base	Cholinesterase (ChE)	Neurological Disease Cancer
(R)-Donepezil is a R-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent *AChE* inhibitor .

HY-B0830

Isoprocarb	Environmental Pollutants Cholinesterase (ChE)	Neurological Disease
Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an *AChE* inhibitor .

HY-B0832R

Profenofos (Standard)	Reference Standards Cholinesterase (ChE) Insecticide	Neurological Disease
Profenofos (Standard) is the analytical standard of Profenofos. This product is intended for research and analytical applications. Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-116026

3-Hydroxycarbofuran	Drug Metabolite Cholinesterase (ChE)	Neurological Disease
3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .

HY-118165

Phenthoate 2 Publications Verification	Environmental Pollutants Cholinesterase (ChE)	Neurological Disease
Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a *AChE* inhibitor .

HY-134137

Donepezil N-oxide	Cholinesterase (ChE) Drug Metabolite	Neurological Disease
Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor .

HY-14566A

(S)-Donepezil (S)-E2020 free base	Cholinesterase (ChE)	Neurological Disease Cancer
(S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent *AChE* inhibitor .

HY-W077226

AChE-IN-23	Cholinesterase (ChE)	Neurological Disease
AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-106440

Zifrosilone	Cholinesterase (ChE)	Neurological Disease
Zifrosilone is an orally active acetylcholinesterase (AChE) inhibitor with a mean maximum inhibition of 20.9% at 10 mg. Zifrosilone can be used for the research of neurological disease .

HY-76299S

Galanthamine-d6	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-d₆ (Galantamine-d₆) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-119419

Pirimicarb	Environmental Pollutants Cholinesterase (ChE) Parasite	Neurological Disease
Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an *AChE* inhibitor and an acaricide .

HY-N2043

Huperzine B	Cholinesterase (ChE)	Neurological Disease
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-148108

AChE-IN-27	Cholinesterase (ChE)	Neurological Disease
AChE-IN-27 (compound 8c) is an *AChE* inhibitor (IC₅₀=0.19 µM). AChE-IN-27 can be used in studies of neurological diseases such as alzheimer's disease, dementia, ataxia and myasthenia gravis .

HY-180448

Galactamine	Cholinesterase (ChE)	Neurological Disease
Galactamine is an AChE inhibitor. Galactamine can be used in the research of Alzheimer's disease .

HY-N8755

Chikusetsusaponin Ib	Cholinesterase (ChE)	Neurological Disease
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent *AChE* inhibitor .

HY-N6619A

Lycoramine	Cholinesterase (ChE)	Neurological Disease
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-N15414

Demethoxykanugin Desmethoxykanugin	Cholinesterase (ChE)	Neurological Disease Cancer
Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .

HY-N11711

Pumiloside	Cholinesterase (ChE)	Others
Pumiloside is a natural product that can be isolated from Nauclea officinalis. Pumiloside is a *AchE* inhibitor with IC₅₀ value of 118.36 μM .

HY-131413

O-Desmethyl Galanthamine Sanguinine	Cholinesterase (ChE)	Neurological Disease
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM .

HY-178750

AChE-IN-96	Cholinesterase (ChE)	Neurological Disease
AChE-IN-96 (Compound 8a) is an *AChE* inhibitor, with an IC₅₀ of 0.697 μM. AChE-IN-96 can be used for the study of neurodegenerative diseases such as Alzheimer's disease (AD) .

HY-106412A

Stacofylline hydrochloride S 9977	Drug Derivative Cholinesterase (ChE)	Neurological Disease
Stacofylline hydrochloride (S 9977), a Xanthine (HY-W017389) derivative, is a potent *AChE* inhibitor with an IC₅₀ of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities .

HY-170811

DCDQ	Cholinesterase (ChE)	Neurological Disease
DCDQ is a potent acetylcholinesterase (AChE) inhibitor. DCDQ shows a strong binding affinity with the 4EY7 protein (binding energy: −8.2 kcal/mol). DCDQ is promising for research of Alzheimer's disease (AD) .

HY-14566S

Donepezil-d7 hydrochloride E2020-d₇	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Donepezil-d₇ (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-156372

AChE-IN-44	Cholinesterase (ChE)	Neurological Disease
AChE-IN-44 (Compound Tap4) is an *AChE* inhibitor. AChE-IN-44 can be converted into the thiazole salt AChE inhibitor Tat2 .

HY-N2219

Picfeltarraegenin X	Cholinesterase (ChE)	Neurological Disease
Picfeltarraenin X, a triterpenoid isolated, is an *AChE* inhibitor .

HY-W782096

Salvianolic acid H	Cholinesterase (ChE)	Cardiovascular Disease
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-N13924

Arisugacin D	Cholinesterase (ChE)	Neurological Disease
Arisugacin D is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 3.5 μM .

HY-N12388

AChE-IN-46	Cholinesterase (ChE)	Neurological Disease
AChE-IN-46 (compound 4), a β-cyclocostunolide, is an *AChE* inhibitor .

HY-156356

AChE-IN-42	Cholinesterase (ChE)	Neurological Disease
AChE-IN-42 (Compound 28) is an *AChE* inhibitor (K_i: 0.44?μM) .

HY-N10425

2-Hydroxyalbrassitriol	Cholinesterase (ChE)	Neurological Disease
2-Hydroxyalbrassitriol (Compound 6) is an *AChE* inhibitor with an IC₅₀ of 35.97 μM .

HY-105157

Icopezil CP-118,954	Cholinesterase (ChE)	Neurological Disease
Icopezil is a selective acetylcholinesterase (AchE) inhibitor. Icopezil can be used in Alzheimer's disease research .

HY-155714

AChE-IN-35	Cholinesterase (ChE)	Neurological Disease
AChE-IN-35 (compound 5g) is an *AChE* inhibitor with the IC₅₀ of 5.88 μM .

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Cholinesterase (ChE)	Metabolic Disease
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor with the IC₅₀ of 2.04 μM .

HY-N4261R

Dehydronuciferine (Standard)	Reference Standards Cholinesterase (ChE)	Metabolic Disease
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL .

HY-149888

AChE-IN-31	Cholinesterase (ChE)	Neurological Disease
AChE-IN-31 (compound 1) is a non-competitive *AChE* inhibitor with potential for the study of Alzheimer's disease .

HY-76299S1

Galanthamine-O-methyl-d3	Cholinesterase (ChE) Apoptosis	Neurological Disease
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-76299

Galanthamine Maximum Cited Publications 15 Publications Verification Galantamine	Alkaloids other families Other Alkaloids Plants Source Classification	Cholinesterase (ChE) Apoptosis
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N6608

Physostigmine 2 Publications Verification Eserine	Alkaloids Lablab purpureus (L.) Sweet Leguminosae Plants Indole Alkaloids Source Classification	Cholinesterase (ChE)
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-N0826

Corynoline 5+ Cited Publications	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Cholinesterase (ChE) Keap1-Nrf2 Heme Oxygenase (HO) COX NO Synthase p38 MAPK JNK Apoptosis Bcl-2 Family Caspase STAT Interleukin Related
Corynoline is an orally active acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM. Corynoline exhibits multiple activities including anti-inflammatory, antinociceptive, antitumor and analgesic effects. Corynoline can be used in the research of diseases such as tumors and inflammatory pain .

HY-N0923

Corydaline 1 Publications Verification (+)-Corydaline; Corydalin	Alkaloids Corydalis yanhusuo W. T. Wang Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an *AChE* inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-A0009

Galanthamine hydrobromide Maximum Cited Publications 15 Publications Verification Galantamine hydrobromide	Alkaloids Other Alkaloids Plants Amaryllidaceae	Cholinesterase (ChE) nAChR
Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid *AChE* inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-W017423

(-)-Carvone	Structural Classification Ketones, Aldehydes, Acids Gymnaster koraiensis Umbelliferae Plants Source Classification	Environmental Pollutants Cholinesterase (ChE)
(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-N5077

Sinapine 2 Publications Verification	Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Cruciferae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Natural Products Verbenaceae Plants Endogenous metabolite Lantana camaraLinn. Source Classification	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (2,3-Dihydrobenzofuran) is an *AChE* inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N0450

Sinapine thiocyanate 2 Publications Verification	Alkaloids Monophenols Classification of Application Fields Other Alkaloids Cruciferae Phenols Plants Disease Research Fields Source Classification Cancer	P-glycoprotein Cholinesterase (ChE)
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N4261

Dehydronuciferine	Alkaloids other families Classification of Application Fields Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Source Classification	Cholinesterase (ChE)
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-76299R

Galanthamine (Standard) Galantamine (Standard)	Alkaloids Structural Classification other families Other Alkaloids Plants Source Classification	Reference Standards Cholinesterase (ChE) Apoptosis
Galanthamine (Standard) is the analytical standard of Galanthamine. This product is intended for research and analytical applications. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N1474

Picfeltarraenin IA	Picria felterrae Lour. Infection Triterpenes Classification of Application Fields Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE)
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N10423

Cubebin (-)-Cubebin	Structural Classification Classification of Application Fields Lignans Piperaceae Piper cubeba L.f. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK
Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active *AChE* inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .

HY-126765

Territrem B	Structural Classification Natural Products Marine natural products Marine microorganism Source Classification	Cholinesterase (ChE)
Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus .

HY-N2211

Picfeltarraenin IB	Infection Triterpenes Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE)
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation .

HY-N2043

Huperzine B	Lycopodiaceae Alkaloids Piperidine Alkaloids Lycopodium serratum Thunb． Pyridine Alkaloids Plants Source Classification	Cholinesterase (ChE)
Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-N11641

Methyl ganoderate A acetonide	Triterpenes Microorganisms Terpenoids Source Classification	Cholinesterase (ChE)
Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent *AChE* inhibitor with an IC₅₀ value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD) .

HY-N8755

Chikusetsusaponin Ib	Triterpenes other families Terpenoids Plants Source Classification	Cholinesterase (ChE)
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent *AChE* inhibitor .

HY-N6619A

Lycoramine	Alkaloids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	Cholinesterase (ChE)
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-N15414

Demethoxykanugin Desmethoxykanugin	Flavonoids Pongamia pinnata (L.) Pierre Flavones Leguminosae Plants Source Classification	Cholinesterase (ChE)
Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .

HY-N11711

Pumiloside	Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Other Alkaloids Rubiaceae Plants Indole Alkaloids Source Classification	Cholinesterase (ChE)
Pumiloside is a natural product that can be isolated from Nauclea officinalis. Pumiloside is a *AchE* inhibitor with IC₅₀ value of 118.36 μM .

HY-131413

O-Desmethyl Galanthamine Sanguinine	Alkaloids Monophenols Cornaceae Phenols Cornus sanguinea Walter Plants Source Classification	Cholinesterase (ChE)
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 1.83 μM .

HY-W643128

Carlina oxide	Natural Products Carlina acaulis L. Plants Compositae Source Classification	Cholinesterase (ChE)
Carlina oxide is an *AChE* inhibitor and antioxidant that kills Culex pipiens larvae (LC50=1.39 μg/mL). Carlina oxide is cytotoxic to vertebrate cells, human dermis, HCT116 and MDA-MB231 cell lines .

HY-N2043R

Huperzine B (Standard)	Lycopodiaceae Alkaloids Piperidine Alkaloids Lycopodium serratum Thunb． Pyridine Alkaloids Plants Source Classification	Reference Standards Cholinesterase (ChE)
Huperzine B (Standard) is the analytical standard of Huperzine B. This product is intended for research and analytical applications. Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease .

HY-N9928

Echinenone	Animals Ketones, Aldehydes, Acids Source Classification	Cholinesterase (ChE)
Echinenone is an acetylcholinesterase (AChE) inhibitor (IC₅₀=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage .

HY-N5077R

Sinapine (Standard)	Alkaloids Structural Classification Monophenols Other Alkaloids Cruciferae Phenols Plants Source Classification	Reference Standards Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-A0009R

Galanthamine hydrobromide (Standard) Galantamine hydrobromide (Standard)	Structural Classification Alkaloids Other Alkaloids Plants Amaryllidaceae Source Classification	nAChR Cholinesterase (ChE) Reference Standards
Galanthamine (hydrobromide) (Standard) is the analytical standard of Galanthamine (hydrobromide). This product is intended for research and analytical applications. Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid *AChE* inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-N2219

Picfeltarraegenin X	Triterpenes Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Source Classification	Cholinesterase (ChE)
Picfeltarraenin X, a triterpenoid isolated, is an *AChE* inhibitor .

HY-W782096

Salvianolic acid H	Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Source Classification	Cholinesterase (ChE)
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-N13924

Arisugacin D	Natural Products Microorganisms Source Classification	Cholinesterase (ChE)
Arisugacin D is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 3.5 μM .

HY-N12388

AChE-IN-46	Natural Products Plants Compositae Inula grandis Schrenk ex Fish.. Source Classification	Cholinesterase (ChE)
AChE-IN-46 (compound 4), a β-cyclocostunolide, is an *AChE* inhibitor .

HY-N10425

2-Hydroxyalbrassitriol	Microorganisms Terpenoids Sesquiterpenes Source Classification	Cholinesterase (ChE)
2-Hydroxyalbrassitriol (Compound 6) is an *AChE* inhibitor with an IC₅₀ of 35.97 μM .

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Alkaloids Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Cholinesterase (ChE)
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor with the IC₅₀ of 2.04 μM .

HY-N4261R

Dehydronuciferine (Standard)	Alkaloids Structural Classification other families Quinoline Alkaloids Plants Source Classification	Reference Standards Cholinesterase (ChE)
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL .

HY-N6619

Lycoramine hydrobromide	Alkaloids other families Plants Source Classification	Cholinesterase (ChE)
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor .

HY-119592

Cyclophostin	Natural Products Microorganisms Source Classification	Cholinesterase (ChE)
Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC₅₀ values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively .

HY-N15707

Isocorydine N-oxide (+)-Isocorydine N-oxide	Alkaloids Glaucium corniculatum (L.) Curtis Quinoline Alkaloids Plants Papaveraceae Source Classification	Cholinesterase (ChE)
Isocorydine N-oxide ((+)-Isocorydine N-oxide), an alkaloidal, a acetylcholinesterase (AChE) inhibitor. Isocorydine N-oxide can be used for the study of Alzheimer's disease .

HY-124140

Heliosupine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Heliotropium indicum L. Other Diseases Plants Disease Research Fields Boraginaceae Source Classification	Cholinesterase (ChE)
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N15450

Undulatine	Alkaloids Crinum moorei Hook. f Other Alkaloids Plants Amaryllidaceae Source Classification	Cholinesterase (ChE)
Undulatine is a potent *AChE* inhibitor with an IC₅₀ of 7.4 μM. Undulatine is able to cross the BBB by passive permeation and can be used in the study of Alzheimer’s disease .

HY-176242

Buphanidrine	Alkaloids Plants Brunsvigia josephinae (Redouté) Ker Gawl. Isoquinoline Alkaloids Amaryllidaceae Source Classification	Others
Buphanidrine is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 52.8 μM. Buphanidrine can be extracted from Brunsvigia josephinae and has potential applications in Alzheimer's disease research .

HY-N12423

Bis-(-)-8-demethylmaritidine	Crinum asiaticum L. Alkaloids Other Alkaloids Plants Amaryllidaceae Source Classification	Cholinesterase (ChE)
Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research .

HY-N7480A

Quinolactacin A1	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Neurological Disease Quinoline Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE)
Quinolactacin A1 is a potent acetylcholinesterase (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease .

HY-N5076

Picfeltarraenin IV	Infection Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Source Classification	Cholinesterase (ChE)
Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation .

HY-124140R

Heliosupine (Standard)	Alkaloids Pyrrole Alkaloids Heliotropium indicum L. Plants Boraginaceae Source Classification	Reference Standards Cholinesterase (ChE)
Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N0826R

Corynoline (Standard)	Alkaloids Structural Classification other families Plants Isoquinoline Alkaloids Source Classification	Reference Standards Cholinesterase (ChE) Keap1-Nrf2
Corynoline (Standard) is the analytical standard of Corynoline. This product is intended for research and analytical applications. Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating Nrf2 .

HY-W017423R

(-)-Carvone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Gymnaster koraiensis Umbelliferae Plants Source Classification	Reference Standards Cholinesterase (ChE)
(-)-Carvone (Standard) is the analytical standard of (-)-Carvone. This product is intended for research and analytical applications. (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-75247R

Coumaran (Standard) 2,3-Dihydrobenzofuran (Standard)	Structural Classification Natural Products Verbenaceae Plants Endogenous metabolite Lantana camaraLinn. Source Classification	Cholinesterase (ChE) Endogenous Metabolite Parasite Reference Standards
Coumaran (Standard) is the analytical standard of Coumaran. This product is intended for research and analytical applications. Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N12622

AChE-IN-58	Structural Classification Flavonoids Flavones Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Cholinesterase (ChE)
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

HY-N2211R

Picfeltarraenin IB (Standard)	Triterpenes Structural Classification Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Source Classification	Reference Standards Cholinesterase (ChE)
Picfeltarraenin IB (Standard) is the analytical standard of Picfeltarraenin IB. This product is intended for research and analytical applications. Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation .

HY-N4027

Hydrangenol 8-O-glucoside Hydrangenol 8-O-β-D-glucopyranoside	Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Cholinesterase (ChE)
Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an *AChE* inhibitor (IC₅₀: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .

Cat. No.	Product Name	Chemical Structure

HY-B0034S

Donepezil-d5 hydrochloride
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-76299S

Galanthamine-d6
Galanthamine-d₆ (Galantamine-d₆) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-B0034S1

Donepezil-d4 hydrochloride
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-14566S

Donepezil-d7 hydrochloride
Donepezil-d₇ (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-N6608S

Physostigmine-d3
Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-B0882S

Edrophonium-d5 chloride

Edrophonium-d₅ chloride is the deuterium labeled Edrophonium chloride (HY-B0882). Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has K_i values of 0.2, 0.2, and 0.4 μM and IC₅₀ values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis .

HY-B0916S

Propoxur-d3

Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

HY-76299S1

Galanthamine-O-methyl-d3
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-118165S

Phenthoate-d6
Phenthoate-d₆ is deuterium labeled Phenthoate. Phenthoate is an organophosphorus pesticide having low toxicity in animals. Phenthoate is also a *AChE* inhibitor .

HY-B0830S

Isoprocarb-d3
Isoprocarb-d₃ is deuterium labeled Isoprocarb. Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an AChE inhibitor .

HY-W753485

Profenofos-d3
Profenofos-d₃ is the deuterium labeled Profenofos (HY-B0832). Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-14566S1

Donepezil-d5
Donepezil-d₅ is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-119419S

Pirimicarb-d6
Pirimicarb-d₆ is the deuterium labeled Pirimicarb (HY-119419). Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide .

HY-W750404

(-)-Carvone-d4
(-)-Carvone-d₄ is the deuterium labeled (-)-Carvone (HY-W017423). (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-14566S3

Donepezil-d4
Donepezil-d₄ (E2020-d₄ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent *AChE* inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-W727525

Donepezil-d7
Donepezil-d₇ (E2020-d₇ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent *AChE* inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-W077226S

AChE-IN-23-d10
AChE-IN-23-d₁₀ (4-Amino-Alpha-diethyl amino-o-cresol-d₁₀ (dihydrochloride)) is the deuterium labeled AChE-IN-23 (HY-W077226). AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-121467S1

Acotiamide-d4

Acotiamide-d₄ (Z-338 (free base)-d₄) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

HY-A0009S

Galanthamine-d3 hydrobromide

Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

HY-B0732AS

Itopride-d6

Itopride-d₆ (HSR803-d₆ (free base)) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .

HY-B2015S

Carbosulfan-d18

Carbosulfan-d₁₈ is the deuterium labeled Carbosulfan. Carbosulfan is an orally active AChE inhibitor that hydrolyzes to Carbofuran in organisms to exert insecticidal effects. Carbosulfan exhibits broad-spectrum insecticidal activity, and it also induces severe oxidative stress by enhancing lipid peroxidation and impairing the antioxidant defense system. Carbosulfan causes reproductive toxicity in male rats and developmental disorders in their offspring. Carbosulfan shows persistence in paddy field environments and potential hazards to non-target organisms, and it is commonly used in studies related to reproductive toxicity and environmental risk assessment .

HY-B1120S

Temephos-d12

Temephos-d₁₂ is the deuterium labeled Temephos. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .

HY-B0828S

Triazophos-d5

Triazophos-d₅ (Hostathion 40EC-d₅) is the deuterium labeled Triazophos(HY-B0828) . Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

HY-W750153

Propoxur-d7

Propoxur-d₇ is the deuterium labeled Propoxur. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

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