1. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  2. Monoamine Oxidase Cholinesterase (ChE) Reactive Oxygen Species
  3. MAO-B-IN-7

MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage.

For research use only. We do not sell to patients.

MAO-B-IN-7 Chemical Structure

MAO-B-IN-7 Chemical Structure

CAS No. : 2851012-65-0

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Description

MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage[1].

IC50 & Target[1]

MAO-B

0.3 μM (IC50)

hAChE

41 nM (IC50)

In Vitro

MAO-B-IN-7 (compound 7d) can effectively interact with Cu2+ to form the corresponding complexes, and has good ability to inhibit ROS’s production induced by Cu2+[1].
MAO-B-IN-7 (10-100 μM; 24 hours) decreases the viability of PC-12 cells at 100 μM, but does not show obvious cytotoxicity at 10 and 25 μM[1].
MAO-B-IN-7 (4-25 μM; 24 hours) protects H2O2-induced PC-12 cells injury, and the cell viability are 80.2%, 71.1% and 56.3% at 25.0 μM, 10.0 μM and 4.0 μM, respectively.[1].
MAO-B-IN-7 (2.5 μM and 10 μM; 8 and 24 hours) inhibits ROS production induced by LPS in BV-2 cells in a dose-dependent manner; inhibits NO production with 30.4%, 43.5% and 58.9% at the concentrations of 0.5 μM, 2.5 μM and 10.0 μM, respectively; also inhibits TNF-α release with 32.7%, 47.8% and 63.2% at the concentrations of μM, 2.5 μM and 10.0 μM, respectively[1].
MAO-B-IN-7 exhibits the parallel artificial membrane permeation of 8.59 × 10-6 in vitro blood-brain barrier permeation study[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line: PC-12[1]
Concentration: 10 μM, 25 μM, 100 μM
Incubation Time: 24 hours
Result: Decreased the viability of PC-12 cells at 100 μM.
Molecular Weight

409.52

Formula

C25H31NO4

CAS No.
SMILES

CCCCC1OC(C2=CC(OCC3=CC(O)=C(C=C3)CN4CCCCC4)=CC=C21)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MAO-B-IN-7
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