AChE-IN-59
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- CAS No.: 2957916-86-6
- Formula: C25H28N2O6
- Molecular Weight:452.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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AChE 0.05 μM (IC50) |
BChE 4.68 μM (IC50) |
Aβ 1-42 |
In Vitro
AChE-IN-59 (compounds 3b) (50/100/500/1000 μg/ mL, 5 min) can inhibit the activity of ChEs, with the IC50 values for AChE and BuChE of 0.05 μM and 4.68 μM, respectively, indicating that AChE-IN-59 is selective for AChE subtype[1].
AChE-IN-59 (50/100/500/1000 μg/ mL, 5 min) shows well antioxidant activity in vitro in tests of Ferric ion reducing antioxidant power (FRAP) and DPPH free radical scavenging capacity[1].
AChE-IN-59 (25 µM, 5 min) has no cytotoxic effect on SH‐SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:SH‐SY5Y
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Concentration:0/6.25/12.5/25/50/100 µM
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Incubation Time:5 h
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Result:Showed a good neuroprotective effect in the range of 6.25-25 µM and did not affect SH‐SY5Y cell viability below 25 µM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:zebrafish juveniles with 5 mg/L AlCl3 model[1]
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Dosage:5/10/25/50/100 μg/mL,
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Administration:Soak drug administration
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Result:Had certain therapeutic effect on AlCl3-induced zebrafish behavior inhibition, which was concentration-dependent. With the increase of compound concentration, the total distance of zebrafish larvae increased gradually.
Chemical Information
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CAS No. 2957916-86-6
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Molecular Weight 452.50
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Formula C25H28N2O6
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SMILES
COC1=CC=C2C=C(C(OC2=C1)=O)NC(C3CCN(CC3)CC4=CC(OC)=CC(OC)=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-59 Related Classifications
HY-157978 Related Classifications
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