2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. AChE-IN-59

AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD).

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AChE-IN-59 Chemical Structure

AChE-IN-59 Chemical Structure

CAS No. : 2957916-86-6

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AChE-IN-59 Related Antibodies

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Description

AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD)[1].

IC50 & Target

AChE

0.05 μM (IC50)

BChE

4.68 μM (IC50)

Aβ 1-42

 

In Vitro

AChE-IN-59 (compounds 3b) (50/100/500/1000 μg/ mL, 5 min) can inhibit the activity of ChEs, with the IC50 values for AChE and BuChE of 0.05 μM and 4.68 μM, respectively, indicating that AChE-IN-59 is selective for AChE subtype[1].
AChE-IN-59 (50/100/500/1000 μg/ mL, 5 min) shows well antioxidant activity in vitro in tests of Ferric ion reducing antioxidant power (FRAP) and DPPH free radical scavenging capacity[1].
AChE-IN-59 (25 µM, 5 min) has no cytotoxic effect on SH‐SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-59 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH‐SY5Y
Concentration: 0/6.25/12.5/25/50/100 µM
Incubation Time: 5 h
Result: Showed a good neuroprotective effect in the range of 6.25-25 µM and did not affect SH‐SY5Y cell viability below 25 µM.
In Vivo

AChE-IN-59 (compounds 3b) (25 μM, 3 days) can alleviate the behavioral effects of AlCl3-induced zebrafish larval movement retardation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: zebrafish juveniles with 5 mg/L AlCl3 model[1]
Dosage: 5/10/25/50/100 μg/mL,
Administration: Soak drug administration
Result: Had certain therapeutic effect on AlCl3-induced zebrafish behavior inhibition, which was concentration-dependent. With the increase of compound concentration, the total distance of zebrafish larvae increased gradually.
Molecular Weight

452.50

Formula

C25H28N2O6
CAS No.
SMILES

COC1=CC=C2C=C(C(OC2=C1)=O)NC(C3CCN(CC3)CC4=CC(OC)=CC(OC)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE-IN-59 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-592957916-86-6Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaAlzheimer's Diseasedual‐targetSH‐SY5YZebrafishInhibitorinhibitorinhibit

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