1. Neuronal Signaling
  2. AChE
    Amyloid-β
  3. Phenserine

Phenserine (Synonyms: (-)-Eseroline phenylcarbamate; (-)-Phenserine)

Cat. No.: HY-103374 Purity: >99.0%
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Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease.

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Phenserine Chemical Structure

Phenserine Chemical Structure

CAS No. : 101246-66-6

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Description

Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3].

IC50 & Target

AChE; β-amyloid precursor protein; β-amyloid peptide[1]

In Vitro

Phenserine (1-25 μM; 48 hours; CHO APP751SW cells) treatment CHO APP751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%[2].

Western Blot Analysis[2]

Cell Line: CHO APP751SW cells
Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM
Incubation Time: 48 hours
Result: 8.6% reduction in cells treated with 10 μM, while 25 μM concentration reduces APP level by 51.4%.
In Vivo

Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task[3].

Animal Model: Male Fischer-344 rats (5 months old) induced by scopolamine[3]
Dosage: 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: Intraperitoneal injection; for 4 days
Result: Improved morris water maze performance of scopolamine-treated rats..
Molecular Weight

337.42

Formula

C₂₀H₂₃N₃O₂

CAS No.

101246-66-6

SMILES

CN1[[email protected]](N(C)CC2)([H])[[email protected]]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

Phenserine(-)-Eseroline phenylcarbamate (-)-PhenserineAChEAmyloid-βAcetylcholinesteraseβ-amyloid peptideAbetaAlzheimer'sdiseasephysostigmineβ-amyloidprecursorproteintranslationcognitiveInhibitorinhibitorinhibit

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