Phenserine tartrate
Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease.
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- CAS No.: 156910-61-1
- Formule: C24H29N3O8
- Masse moléculaire:487.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
AChE; β-amyloid precursor protein; β-amyloid peptide[1]
In Vitro
Phenserine (1-25 μM; 48 hours; CHO APP751SW cells) treatment CHO APP751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO APP751SW cells
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Concentration:1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM
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Incubation Time:48 hours
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Result:8.6% reduction in cells treated with 10 μM, while 25 μM concentration reduces APP level by 51.4%.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Fischer-344 rats (5 months old) induced by scopolamine[3]
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Dosage:1 mg/kg, 2 mg/kg, 4 mg/kg
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Administration:Intraperitoneal injection; for 4 days
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Result:Improved morris water maze performance of scopolamine-treated rats.
Chemical Information
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CAS No. 156910-61-1
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Masse moléculaire 487.50
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Formule C24H29N3O8
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SMILES
OC([C@H](O)[C@@H](O)C(O)=O)=O.C[C@]12C3=CC(OC(NC4=CC=CC=C4)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
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Synonyms
(-)-Eseroline phenylcarbamate tartrate; (-)-Phenserine (+)-tartrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97. [Content Brief]
[2]. Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75(5):684-99. [Content Brief]
[3]. https://www.ncbi.nlm.nih.gov/pubmed/24687915 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenserine tartrate Related Classifications
HY-103374A Related Classifications
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