156910-61-1
Chemical Structure
Phenserine tartrate
Synonym(s): (-)-Eseroline phenylcarbamate tartrate; (-)-Phenserine (+)-tartrate
- CAS No.: 156910-61-1
- Formula:C24H29N3O8
- Molecular Weight:487.50
InChIKey: XKKPTCVQEJZDGT-PWUAAHBCSA-N
SMILES: OC([C@H](O)[C@@H](O)C(O)=O)=O.C[C@]12C3=CC(OC(NC4=CC=CC=C4)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
Biological Activity: Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3].
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Phenserine tartrate | Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97. [Content Brief]
- [2]. Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75(5):684-99. [Content Brief]
- [3]. https://www.ncbi.nlm.nih.gov/pubmed/24687915 [Content Brief]
