Demethyl-Ganstigmine hydrochloride
Demethyl-Ganstigmine hydrochloride (Demethyl-CHF 2819) is an orally active AChE inhibitor. Demethyl-Ganstigmine hydrochloride promotes the release of sAPPα from neuroblastoma cells. Demethyl-Ganstigmine hydrochloride increases the concentration of acetylcholine in the prefrontal cortex of rats. Demethyl-Ganstigmine hydrochloride is used in research on neurological diseases such as Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 412044-92-9
- Formula: C21H26ClN3O3
- Molecular Weight:403.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 412044-92-9
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Molecular Weight 403.90
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Formula C21H26ClN3O3
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SMILES
O=C(OC1=CC2=C(N[C@]3([H])[C@@]2(C)CC[N@+]3([O-])C)C=C1)NC4=CC=CC=C4CC.Cl
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Synonyms
Demethyl-CHF 2819
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Trabace L, et al. Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel acetylcholinesterase inhibitor, in rat prefrontal cortex: an in vivo study. Pharmacol Res. 2007 Oct;56(4):288-94. [Content Brief]
[2]. Mazzucchelli M, et al. Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells. J Neural Transm (Vienna). 2003 Aug;110(8):935-47. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Demethyl-Ganstigmine hydrochloride Related Classifications
HY-118928 Related Classifications
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