412044-92-9
Chemical Structure
Demethyl-Ganstigmine hydrochloride
Synonym(s): Demethyl-CHF 2819
- CAS. Nr.: 412044-92-9
- Formula:C21H26ClN3O3
- Molecular Weight:403.90
IUPAC Name: (1R,3aS,8aS)-5-(((2-ethylphenyl)carbamoyl)oxy)-1,3a-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole 1-oxide hydrochloride
InChIKey: CVDHRWXJJRBPFA-FKXUWVMKSA-N
SMILES: O=C(OC1=CC2=C(N[C@]3([H])[C@@]2(C)CC[N@+]3([O-])C)C=C1)NC4=CC=CC=C4CC.Cl
Biological Activity: Demethyl-Ganstigmine hydrochloride (Demethyl-CHF 2819) is an orally active AChE inhibitor. Demethyl-Ganstigmine hydrochloride promotes the release of sAPPα from neuroblastoma cells. Demethyl-Ganstigmine hydrochloride increases the concentration of acetylcholine in the prefrontal cortex of rats. Demethyl-Ganstigmine hydrochloride is used in research on neurological diseases such as Alzheimer's disease[1][2].
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Demethyl-Ganstigmine hydrochloride | Demethyl-Ganstigmine hydrochloride (Demethyl-CHF 2819) is an orally active AChE inhibitor. Demethyl-Ganstigmine hydrochloride promotes the release of sAPPα from neuroblastoma cells. Demethyl-Ganstigmine hydrochloride increases the concentration of acetylcholine in the prefrontal cortex of rats. Demethyl-Ganstigmine hydrochloride is used in research on neurological diseases such as Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Trabace L, et al. Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel acetylcholinesterase inhibitor, in rat prefrontal cortex: an in vivo study. Pharmacol Res. 2007 Oct;56(4):288-94. [Content Brief]
- [2]. Mazzucchelli M, et al. Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells. J Neural Transm (Vienna). 2003 Aug;110(8):935-47. [Content Brief]
